Excretion of potassium ion by prostanoic acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514573, A61K 31215, A61K 31557

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active

RE0347566

ABSTRACT:
Amethod for inducing decrease in potassium ion concentration in the blood which comprises administering, to a subject having an increased potassium ion concentration in the blood, a prostanoic acid derivative in an amount effective in inducing decrease in potassium ion concentration in the blood wherein said concentration is increased or for improving extracorporeal excretion of potassium ion in the blood which comprises administering, to a subject having an increased potassium ion concentration in the blood, a prostanoic acid derivative in an amount effective in improving extracorporeal excretion of potassium ion concentration is increased.

REFERENCES:
Chem. Abst. 90: 118674 (1979).
E. Anggard, "The Biological Activites of Three Metabolites of Prostaglandin E.sub.1 ", Acta physiol. scand., (1966), 66, 509-510.
Inazu et al, "Effect of 13, 14-Dihydroprostaglandin F.sub.2.alpha. on Steroid Biosynthesis in Rat Ovary", Japan. J. Pharmacol., (1981), 31, 301-303.
Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Ed., Supplement Volume, p. 719 (1978).
Index Medicus, (item 1 from file: 155), Sy. Tan et al.: "Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism:" & Ann Intern Med May 1979, 90 (5) pp. 783-785.
Biological Abstracts, Biosis No. 67059604; L. H. Norby et al.: "Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninemic hpoaldosteronism" & Lancet 2 (*100). 1978 1118-1121.
Prostaglandins, vol. 20, No. 1, Jul. 1980, pp. 15-23; J. Hahn et al.: "Induction of renin release by exogenous prostaglandins in hporeninemic hypoaldosteronism".
Acta Physiol. Scand. (1966), 66, 509-510.
Prostaglandins, 11, 809-827 (1976).

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