Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1996-04-02
1998-12-01
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
514277, 514345, 514351, 514359, 514381, 514384, 514461, 514473, 514562, 544316, 548253, 5482644, 5482672, 549 55, 549438, 549461, 549466, 560 38, 560 39, 562441, 562443, 562444, A61K 31435, C07C22936
Patent
active
058439978
ABSTRACT:
The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods for the preparation of the novel compounds.
REFERENCES:
patent: 5589501 (1996-12-01), Carrera et al.
Hon, Heterocycles 31 (2) 191, 1990.
Tetrahedron Letters, vol. 30, No. 29, pp. 3799-3802, 1989, Miwa Yanagidaet al., `Synthesis of acyclic analogues of kainoids and neuroexcitatory activity`.
Tetrahedron Letters, vol. 31, No. 2, pp. 283-284, 1990. Michael R. Attwood et al., `A new synthetic equivalent of the glutamic acid .gamma.anion and its application to the synthesis of S-(+)-.gamma.-carboxyglutamic acid`.
J. Org. Chem., 1991, 56, 5729-5733, Isabelle Jako et al, `Stereoselective synthesis of 3-alkylated glutamic acids: application to the synthesis of secokainic acid`.
Ohta, Hosoi, and Nozoe, "Stereoselective Hydroxylation of N-Carbamoyl-L-Pyroglutamate. Synthesis of (-)-Bulgecinine", Tet. Lett., 29, 329-332 (1988).
Chang, et al., "Study of the stereoselectivity of L-glutamate receptors by synthetic 4 (R)-and 4(S)-substituted L-glutamate analogues", Brain Research, 604, 86-69 (1993).
Hon, Chan, and Gong, "Synthesis of (2S, 4S) and (2S, 4R) -4-Substituted Glutamic Acid Analogues For Neuroexcitatory Activity Studies", Heterocycles, 31, 191-195 (1990).
Baldwin, et al., "Stereospecific Amino Acid Synthesis; Preparation of the .gamma.-Anion derived from Glutamic Acid", J. Chem. Soc., Commun, 828-829 (1988).
Cunningham J. Physiol (London) 1985 366. 46-62 (Abstract).
Chemical Abstracts, 100, 22279h, 16 Jan. 1984.
Chemical Abstracts, 96, 163139y, 10 May 1982.
Chemical Abstracts, 75, 59821v, 30 Aug. 1971.
Heinz Lawrence J.
Lunn William H.W.
Schoepp Darryle Darwin
Boone David E.
Eli Lilly and Company
Gerstl Robert
Hay Martin A.
LandOfFree
Excitatory amino acid receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Excitatory amino acid receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Excitatory amino acid receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2396102