Excitatory amino acid receptor antagonists

Details Excitatory amino acid receptor antagonists Excitatory amino acid receptor antagonists

1995-07-10

1998-02-10

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514454, 514461, 514514, 514531, 514538, 514566, 5483191, 549 72, 549390, 560 20, 560 36, 560 45, 560 46, 560 47, 562433, 562435, 562441, 562442, 562444, 562451, 562456, 562458, A61K 3119, C07C10120, C07D20904, C07D33322, C07D 3180, C07C22900, C07C20700

Patent

active

057171092

ABSTRACT:
The present invention provides compounds of formula ##STR1## in which R represents an organic group, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as antagonists of one or more of the actions of L-glutamate at metabotropic excitatory amino acid receptors.

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Br. J. Pharmacol. (1994), 112, 809-816; Actions of two new antagonists showing selectivity for different subtypes of metabotropic glutamate receptor in the neonatal rat spinal cord. Jane et al.
Tetrahedron Letters, vol. 30, No. 29, pp. 3803-3804, 1989 New Routes to the Synthesis of CIS-a-(carboxycyclopropyl) glycines from 1-glutamic acid, conformationally restricted analogues of the excitatory neurotransmitter 1-glutamic acid (Shimamoto et al).
Tetrahedron Letters, vol. 29, No. 10, pp. 1181-1184, 1988 Synthesis of Trans-and CIS-a-(carboxycyclopropyl) glycines, novel neuroinhibitory amino acids as 1-glutamate analogue (Yamanoi et al).

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