Excitatory amino acid receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546147, C07D21514, A61K 3147

Patent

active

056705166

ABSTRACT:
This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.

REFERENCES:
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patent: 5071859 (1991-12-01), Knudsen et al.
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LePeillet et al., "The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and straital cell loss following transient global ischaemia in the rat", Brain Research, 571, 115-120 (1992).
Ornstein et al., "Synthesis of 6-Oxodecahydroisoquinoline-3-carboxylates. Useful Intermediates for the Preparation of Conformationally Defined Excitatory Amino Acid Antagonists", J. Org. Chem., 56, 4388-4392 (1991).
Jacques et al., Enantiomers, Racemates, and Resolutions, 253-259, John Wiley and Sons, N.Y., (1981).
Ornstein et al., "6-Substituted Decahydroisoquinoline-3-carboxylic Acids as Potent and Selective Conformationally Constrained NMDA Receptor Antagonists", J. Med. Chem., 35, 3547-3560 (1992).
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