Excitatory amino acid receptor antagonists

Details Excitatory amino acid receptor antagonists Excitatory amino acid receptor antagonists

2007-04-17

2007-04-17

Davis, Zinna N. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S231500, C544S128000, C546S146000

Reexamination Certificate

active

10450667

ABSTRACT:
The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine, comprising administering a compound of Formula (I) or Formula (I(a)); and processes for preparing compounds of Formula (I) or Formula (I(a)).

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Y. Sahara, et al., “Glutamate Receptor Subunits GluR5 and KA-2 Are Coexpresses in Rat Trigeminal Ganglion Neurons,”The Journal of Neuroscience, 17(17), pp. 6611-6620 (1997).
Z. Alam, et al., “Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache,”Journal of Neurological Sciences, 156, pp. 102-106 (1998).
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O'Neill, M.J., et al., “Decahydroisoquinolines: Novel competitive AMPA/kainite antagonists with neuroprotective effects in global cerebral ischemia,” Neuropharmacology 37 (1998) 1211-1222.
Proctor, M.J., et al., “Actions of kainite and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord,” Neuropharmacology 37 (1998) 1287-1297.
Bleakman, D., “Kainate receptor pharmacology and physiology,” Cellular and Molecular Life Sciences, 56/7-8 (1999) 558-556.
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May, Chemical Abstracts Registry No. 365530-78-5; Nov. 1, 2001; American Chemical Society (corresponds to Example 38 (step A)).
May, Chemical Abstracts Registry No. 365530-79-6; Nov. 1, 2001; American Chemical Society.
May, Chemical Abstracts Registry No. 365530-80-9; Nov. 1, 2001; American Chemical Society (corresponds to Example 9).
May, Chemical Abstracts Registry No. 365530-81-0; Nov. 1, 2001; American Chemical Society (corresponds to Example 10).
May, Chemical Abstracts Registry No. 365530-82-1; Nov. 1, 2001; American Chemical Society (corresponds to free base of Example 9).
May, Chemical Abstracts Registry No. 365530-83-2; Nov. 1, 2001; American Chemical Society (corresponds to Examples 37 and 38).
May, Chemical Abstracts Registry No. 365530-84-3; Nov. 1, 2001; American Chemical Society (corresponds to hydrate of Example 9).
May, Chemical Abstracts Registry No. 365530-85-4; Nov. 1, 2001; American Chemical Society (corresponds to free base of Example 9).
Bleisch, et al., “Structure-Activity Studies of Aryl-Spaced Decahydroisoquinoline-3-Carboxylic Acid AMPA Receptor Antagonist,” Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 9 pp. 1161-1166 (1997).
Martinez-Perez, “Structure-Activity Study of Glu5 Kainate Receptor Antagonists-Application of a Prodrug Strategy for Oral Efficacy in Pain Models” (oral presentation given by one of the named inventors at the Frontiers in Medicinal Chemistry Meeting, Leipzig, Germany Mar. 15, 2005.

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