Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-08-02
2005-08-02
Chang, Ceila (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S307000, C546S146000, C546S147000
Reexamination Certificate
active
06924294
ABSTRACT:
The present invention provides novel compounds of Formula (I), or the pharmaceutically acceptable salts or prodrugs thereof, and methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine.
REFERENCES:
patent: 5356902 (1994-10-01), Ornstein
patent: 5446051 (1995-08-01), Ornstein
patent: 5767117 (1998-06-01), Moskowitz
patent: 0 590 789 (1994-04-01), None
patent: WO 98/45270 (1998-10-01), None
patent: WO 01/01972 (2001-01-01), None
patent: WO 01/02367 (2001-01-01), None
patent: WO 01/46173 (2001-06-01), None
Y. Sahara, et al., “Glutamate Receptor Subunits GluR5 and KA-2 Are Coexpressed in Rat Trigeminal Ganglion Neurons,” The Journal of Neurosciences, vol. 17, No. 17, pp. 6611-6620 (1997)
Z. Alam, et al., “Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache,” Journal of Neurological Sciences, vol. 156, pp. 102-106 (1998).
Procter, et al., “Possible role of Glu54 glutamate receptors in spinal nociceptive processing in the anaesthetized rat,” Journal of Physiology, 504.P, 101P-102P (1997).
Nikam, et al., The search fof AMPA/Gly(N) receptor antagonists: Drugs of the Future, vol. 24, No. 10, pp. 1107-1124 (1999).
Proctor, et al., “Actions of kainite and AMPA selective glutamate receptor ligands on nociceptiv processing in the spinal cord,” Neuropharmacology, vol. 37, pp. 1287-1297 (1998).
Bleakman, et al., “Kainate receptor pharmacology and physiology,” Cellular and Molecular Life Sciences, 56/7-8 (1999) 558-556.
National Library of Medicine (NLM), Bethesda, MD, US: Mitsilostas, et al., “Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis,” Database accession No. 10003939 & British Journal of Pharmacology, vol. 127, No. 3, pp. 623-630 (1999).
Bleisch Thomas John
Castano Mansanet Ana Maria
Dominguez-Manzanares Esteban
Escribano Ana Maria
Chang Ceila
Coppins Janet L
Eli Lilly and Company
Wilson Alexander
LandOfFree
Excitatory amino acid receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Excitatory amino acid receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Excitatory amino acid receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3514196