Excitatory amino acid receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514269, 514471, 514561, 514562, 514567, 544335, 549475, 549476, 562427, 562430, 562432, 562457, 562500, A01N 4354, C07D30702, C07D23902, C07C31500

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active

059122480

ABSTRACT:
Compounds of the formula ##STR1## in which X represents a bond, S, SO or SO.sub.2 ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.

REFERENCES:
D. Schoepp, et al., "Selective Inhibition of Forskolin-stimulated Cyclic AMP Formation in Rat Hippocampus by a Novel mGluR Agonist, 2R, 4R-4-aminopyrrolidine-2,4-dicarboxylate", Neuropharmacology, 34(8), 843-850 (1995).
D. Schoepp, et al., "Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors", TiPS, 11(12), 508-515 (1990).
D. Schoepp, et al., "Metabotropic glutamate receptors in brain function and pathology", TiPS, 14, 13-20 (1993).
Chemical Abstract vol. 107 No. 217322, Rizzo et al, "A convenient preparation of 4 and 5-substituted cyclopentenones", 1987.

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