Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-11-14
1999-06-15
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514269, 514471, 514561, 514562, 514567, 544335, 549475, 549476, 562427, 562430, 562432, 562457, 562500, A01N 4354, C07D30702, C07D23902, C07C31500
Patent
active
059122480
ABSTRACT:
Compounds of the formula ##STR1## in which X represents a bond, S, SO or SO.sub.2 ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.
REFERENCES:
D. Schoepp, et al., "Selective Inhibition of Forskolin-stimulated Cyclic AMP Formation in Rat Hippocampus by a Novel mGluR Agonist, 2R, 4R-4-aminopyrrolidine-2,4-dicarboxylate", Neuropharmacology, 34(8), 843-850 (1995).
D. Schoepp, et al., "Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors", TiPS, 11(12), 508-515 (1990).
D. Schoepp, et al., "Metabotropic glutamate receptors in brain function and pathology", TiPS, 14, 13-20 (1993).
Chemical Abstract vol. 107 No. 217322, Rizzo et al, "A convenient preparation of 4 and 5-substituted cyclopentenones", 1987.
Fernandez Carmen Dominguez
Monn James Allen
Valli Matthew John
Covington Raymond
Eli Lilly and Company
Hay Martin A.
Kight John
LandOfFree
Excitatory amino acid receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Excitatory amino acid receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Excitatory amino acid receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-402699