Excitatory amino acid derivatives

Details Excitatory amino acid derivatives Excitatory amino acid derivatives

1996-11-14

1997-11-18

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514409, 514412, 514462, 514469, 548410, 548452, 549 57, 549344, A61K 3138, C07D30777

Patent

active

056888260

ABSTRACT:
Compounds for formula I ##STR1## in which X represents O, NR.sup.a, S, SO or SO.sub.2 and R is as defined in the specification; and non-toxic metabolically labile esters or amides thereof; and pharmaceutically acceptable salts thereof are useful as modulators of metabotropic glutamate receptor function.

REFERENCES:
patent: 2572842 (1951-10-01), MacDonald
patent: 4536330 (1985-08-01), Doden et al.
D. Schoepp, et al., "Selective Inhibition of Forskolin-stimulated Cyclic AMP Formation in Rat Hoppocampus by a Novel mGluR Agonist, 2R, 4R-1-aminopyrrolidine-2,4-dicarboxylate", Neuropharmacology, 34(8), 843-850 (1995).
D. Schoepp, et al., "Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors", TiPS, 11(12), 508-515 (1990).
D. Schoepp, et al., "Metabotropic glutamate receptors in brain function and pathology", TiPS, 14, 13-20 (1993).
Gillespie, et al., "The Reaction of Diazoalkanes with Thiophen", Journal of the Chemical Society, Perkin Transactions I, No. 7, 2624-2628 (1979).

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