Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-04-24
1990-10-02
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3140
Patent
active
049607863
ABSTRACT:
The present invention is directed to the discovery of a new use for a group of known 2-carboxylic indole derivatives. The compounds are excitatory amino acid antagonists.
REFERENCES:
James E. Huettner, Science, vol. 245, pp. 1611-1613, (1988).
Indole-2-Carboxylic Acid: A Competitive Antagonists of Potentiation by Glycine at the NMDA Receptor, Science, vol. 243, pp. 1611-1613, Dec. 1988, James E. Huettner.
Baron Bruce M.
Harrison Boyd L.
Salituro Francesco G.
Dixon J. Michael
Friedman Stanley J.
Merrell Dow Pharmaceuticals Inc.
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