Excipients for use in adeno-associated virus pharmaceutical...

Details Excipients for use in adeno-associated virus pharmaceutical... Excipients for use in adeno-associated virus pharmaceutical...

2004-06-04

2009-10-06

Mosher, Mary E (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S260000

Reexamination Certificate

active

07598070

ABSTRACT:
Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions.

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