Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1995-11-15
2000-06-13
Fitzgerald, David L.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
424 852, 424 851, 435372, 4353722, 4353723, 435 6952, A61K 3820, C07K 1454, C12N 1524
Patent
active
060746394
ABSTRACT:
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.
REFERENCES:
patent: 4438032 (1984-03-01), Golde et al.
patent: 4810643 (1989-03-01), Souza
patent: 4877729 (1989-10-01), Clark et al.
patent: 4959455 (1990-09-01), Clark
patent: 4999291 (1991-03-01), Souza
patent: 5032395 (1991-07-01), Clark et al.
patent: 5073627 (1991-12-01), Curtis et al.
patent: 5108910 (1992-04-01), Curtis et al.
patent: 5166322 (1992-11-01), Shaw et al.
patent: 5199942 (1993-04-01), Gillis
patent: 5218092 (1993-06-01), Sasaki et al.
patent: 5376367 (1994-12-01), Williams et al.
patent: 5516512 (1996-05-01), Dorssers
patent: 5591427 (1997-01-01), Vadas
patent: 5858347 (1999-01-01), Bauer et al.
Yang et al, Cell; 47:3 (1986).
Dorsers et al, Gene; 55:115 (11987).
Phillips et al; Gene; 84:501 (1989).
Clark-Lewis et al, Science; 231:134 (1986).
Clark-Lewis et al, Proc. Nat. Acad.Sci. USA; 85:7897 (1988).
Lokker et al, J. Biol. Chem.; 266 (16):10624 (1991).
Clark-Lewis et al, Immune Regulation by Characterized Polypeptides; P. 323-334 (1987).
Ihle et al, J. Immunol; 126:2184 (1981).
Fung et al, Nature; 307:233 (1984).
Yokota et al, Proc. Nat. Acad. Sci USA; 81:1070 (1984).
Dorssers et al, J. Biol. Chem.; 266(16):21310 (1991).
Kaushansky et al, J. Clin. Invest; 90:1879 (1992).
Lopez et al, Proc. natl. Acad. Sci. USA; 89:11842-11846 (1992).
Lokker et al, EMBO Jour.; 10:2125-2131 (1991).
Fojo et al, Biochem; vol. 17, 15:3109 (1978).
Pack et al, Bio/Technology; vol. 11, pp. 1271-1277 Nov (1993).
Curtis et al, Proc. Natl. Acad. Sci.; 88:5809 (1991).
Williams et al, Cancer 67:2705-2707 (1991).
Welch et al, Exp. Hem; 21:647-655 (1994).
Haylock, D.N., et al. (1992) Blood 80: 1405-12.
Brenner, M.K. (1995) Cytokines Mol. Ther. 1:3-9.
Abrams Mark Allen
Bauer S. Christopher
Braford-Goldberg Sarah Ruth
Caparon Maire Helena
Easton Alan Michael
Bennett Dennis A.
Fitzgerald David L.
G. D. Searle & Co.
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