Ex vivo expansion of hematopoietic cells using interleukin-3 (IL

Details Ex vivo expansion of hematopoietic cells using interleukin-3 (IL Ex vivo expansion of hematopoietic cells using interleukin-3 (IL

1995-11-15

2000-06-13

Fitzgerald, David L.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

424 852, 424 851, 435372, 4353722, 4353723, 435 6952, A61K 3820, C07K 1454, C12N 1524

Patent

active

060746394

ABSTRACT:
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.

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