EX vivo effector cell activation for target cell killing

Details EX vivo effector cell activation for target cell killing EX vivo effector cell activation for target cell killing

1986-10-07

1989-07-04

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 93, 4352402, 530387, 530828, 530388, 530808, A61K 39395

Patent

active

048448931

ABSTRACT:
A method and composition for killing target cells is disclosed. The method utilizes ex vivo IL-2 activation of leucocyte effector cells and arming the activated leucocyte effectors with monoclonal antibodies whose Fc portions bind to the IL-2-activated effectors and whose paratopic portions immunoreact with an epitope expressed on the surfaces of the target cells. The composition contains a cytolytic amount of the armed, IL-2-activated effector cells dispersed in an aqueous physiologically tolerable diluent medium.

REFERENCES:
patent: 4444878 (1984-04-01), Paulus
patent: 4507391 (1985-03-01), Pukel et al.
patent: 4675287 (1987-06-01), Reisfeld
Honsik, C. J. et al., Proc. Natl. Acad. Sci., U.S.A., 83:7893-7897, (10-1986).
Cheresh, D. A. et al., Proc. Natl. Acad. Sci., U.S.A., 82:5155-5159, (8-1985).
Park, M. M. et al., Cellular Immunology, 84:94-103, (1984).
Mule, J. J. et al., Science, 225:1487-1489, (9-1984).
Rosenberg, S. et al., New Engl. J. Medicine, 313(23):1485-1492, (12-1985).
Perez, P. et al., J. Exper. Med., 163:166-178, (1-1986).
Jung, G. et al., Proc. Natl. Acad. Sci., U.S.A., 83:4479-4483, (6-1986).
Staerz, U. D. et al., Nature, 314:628-631, (4-1985).
Cancer Research, (1984), 44:806-809, Dippold et al.
Natural Immunity and Biological Response, (1985), 4:253, Honsik et al.
Eur. J. Immunol., (1986), 16:263-270, Staerz et al.
Proc. Nat'l Acad. Sci. U.S.A., (1986), 83:1453-1457, Staerz et al.
Proc. Nat'l Acad. Sci. U.S.A., (1985), 82:1242-1246, Houghton et al.

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