Evolving new molecular function

Details Evolving new molecular function Evolving new molecular function

2003-08-19

2009-02-17

Benzion, Gary (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C506S001000, C506S016000, C506S009000

Reexamination Certificate

active

07491494

ABSTRACT:
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 4863857 (1989-09-01), Blalock et al.
patent: 5162218 (1992-11-01), Schultz
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5449602 (1995-09-01), Royer et al.
patent: 5539082 (1996-07-01), Nielsen et al.
patent: 5547835 (1996-08-01), Köster
patent: 5559000 (1996-09-01), Janda et al.
patent: 5573905 (1996-11-01), Lerner et al.
patent: 5574141 (1996-11-01), Seliger et al.
patent: 5597697 (1997-01-01), Diamond
patent: 5605798 (1997-02-01), Köster
patent: 5622824 (1997-04-01), Köster
patent: 5637682 (1997-06-01), Nieuwlandt et al.
patent: 5639603 (1997-06-01), Dower et al.
patent: 5677195 (1997-10-01), Winkler et al.
patent: 5691141 (1997-11-01), Köster
patent: 5698685 (1997-12-01), Summerton et al.
patent: 5708153 (1998-01-01), Dower et al.
patent: 5719262 (1998-02-01), Buchardt et al.
patent: 5721099 (1998-02-01), Still et al.
patent: 5723289 (1998-03-01), Eaton et al.
patent: 5723598 (1998-03-01), Lerner et al.
patent: 5770358 (1998-06-01), Dower et al.
patent: 5770367 (1998-06-01), Southern et al.
patent: 5786461 (1998-07-01), Buchardt et al.
patent: 5789160 (1998-08-01), Eaton et al.
patent: 5789162 (1998-08-01), Dower et al.
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5840485 (1998-11-01), Lebl et al.
patent: 5843701 (1998-12-01), Gold et al.
patent: 5846839 (1998-12-01), Gallop et al.
patent: 5851765 (1998-12-01), Köster
patent: 5858660 (1999-01-01), Eaton et al.
patent: 5872003 (1999-02-01), Köster
patent: 5888819 (1999-03-01), Goelet et al.
patent: 5922545 (1999-07-01), Mattheakis et al.
patent: 5945325 (1999-08-01), Arnold et al.
patent: 5958691 (1999-09-01), Pieken et al.
patent: 5958703 (1999-09-01), Dower et al.
patent: 5986053 (1999-11-01), Ecker et al.
patent: 5998140 (1999-12-01), Dervan et al.
patent: 6037120 (2000-03-01), Brenner
patent: 6043031 (2000-03-01), Koster et al.
patent: 6048698 (2000-04-01), Eaton et al.
patent: 6060596 (2000-05-01), Lerner et al.
patent: 6074823 (2000-06-01), Köster
patent: 6080826 (2000-06-01), Grubbs et al.
patent: 6127154 (2000-10-01), Mosbach et al.
patent: 6140053 (2000-10-01), Köster
patent: 6140493 (2000-10-01), Dower et al.
patent: 6140496 (2000-10-01), Benner
patent: 6143497 (2000-11-01), Dower et al.
patent: 6165717 (2000-12-01), Dower et al.
patent: 6175001 (2001-01-01), Barbas et al.
patent: 6194144 (2001-02-01), Köster
patent: 6194550 (2001-02-01), Gold et al.
patent: 6207446 (2001-03-01), Szostak et al.
patent: 6214553 (2001-04-01), Szostak et al.
patent: 6225450 (2001-05-01), Köster
patent: 6238871 (2001-05-01), Köster
patent: 6287765 (2001-09-01), Cubicciotti
patent: 6291160 (2001-09-01), Lerner et al.
patent: 6291161 (2001-09-01), Lerner et al.
patent: 6368874 (2002-04-01), Gallop et al.
patent: 6436635 (2002-08-01), Fu et al.
patent: 6607878 (2003-08-01), Sorge
patent: 6680192 (2004-01-01), Lerner et al.
patent: 7070928 (2006-07-01), Liu et al.
patent: 2001/0036638 (2001-11-01), Nolan et al.
patent: 2002/0034757 (2002-03-01), Cubicciotti
patent: 2002/0038000 (2002-03-01), Gold et al.
patent: 2002/0064798 (2002-05-01), Nolan et al.
patent: 2003/0099945 (2003-05-01), Eaton et al.
patent: 2003/0104389 (2003-06-01), Sergeev
patent: 2003/0113738 (2003-06-01), Liu et al.
patent: 2003/0143561 (2003-07-01), Pedersen et al.
patent: 2004/0014090 (2004-01-01), Neri et al.
patent: 2004/0049008 (2004-03-01), Pedersen et al.
patent: 2005/0025766 (2005-02-01), Liu et al.
patent: 2005/0042669 (2005-02-01), Liu et al.
patent: 2005/0142583 (2005-06-01), Liu et al.
patent: 2005/0170376 (2005-08-01), Liu et al.
patent: 2005/0227281 (2005-10-01), Liu et al.
patent: 2005/0233381 (2005-10-01), Liu et al.
patent: 2005/0281819 (2005-12-01), Liu et al.
patent: 2006/0223086 (2006-10-01), Liu et al.
patent: 196 46 372 (1996-11-01), None
patent: 0 324 616 (1989-07-01), None
patent: 0 604 552 (1997-02-01), None
patent: 0 773 227 (1997-05-01), None
patent: 0 643 778 (2000-05-01), None
patent: WO 91/05058 (1991-04-01), None
patent: WO 92/02536 (1992-02-01), None
patent: WO 93/06121 (1993-04-01), None
patent: WO 93/20242 (1993-10-01), None
patent: WO 96/09316 (1995-09-01), None
patent: WO 00/23458 (2000-04-01), None
patent: WO-00/32823 (2000-06-01), None
patent: WO 00/47775 (2000-08-01), None
patent: WO 00/61775 (2000-10-01), None
patent: WO00/61775 (2000-10-01), None
patent: WO-01/16352 (2001-03-01), None
patent: WO 02/074929 (2002-09-01), None
patent: WO 02/102820 (2002-12-01), None
patent: WO 02/103008 (2002-12-01), None
patent: WO 03/078050 (2003-09-01), None
patent: WO 03/078445 (2003-09-01), None
patent: WO 03/078446 (2003-09-01), None
patent: WO 03/078625 (2003-09-01), None
patent: WO 03/078626 (2003-09-01), None
patent: WO 03/078627 (2003-09-01), None
patent: WO 03/082901 (2003-10-01), None
patent: WO 2004/001042 (2003-12-01), None
patent: WO 2004/013070 (2004-02-01), None
patent: WO 2004/016767 (2004-02-01), None
patent: WO 2004/024929 (2004-03-01), None
patent: WO 2004/039825 (2004-05-01), None
patent: WO 2004/056994 (2004-07-01), None
patent: WO 2004/074429 (2004-09-01), None
patent: WO 2004/074501 (2004-09-01), None
patent: WO 2004/083427 (2004-09-01), None
patent: WO 2004/110964 (2004-12-01), None
Landegren et al. (Science, 1988, vol. 241, No. 4869, p. 1077-1080).
Gartner and Liu (J. Am. Chem. Soc., 2001, vol. 213, p. 6961-6963).
Bruick et al. (Current Biology, 1996, vol. 3, p. 49-56).
Summerer and Marx (Angew. Chem. Int. Ed. 2002, vol. 41, No. 1, p. 89-90).
Gartner and Liu (J. Am. Chem. Soc., 2001, vol. 123, p. 6961-6963).
Dorner et al. (Journal of Virology, 1984, vol. 50, No. 3, p. 507-514).
Brooker (Genetics Analysis and Principles, 1999, edition 1, Menlo Park, CA), pp. 326, 368, 372, 373, 379.
supporting information for Gartner and Liu manuscript, 2 pages.
Acevedo et al., “Non-Enzymatic Transcription of an Oligodeoxynucleotide 14 Residues Long”J. Mol. Biol.197: 187-193 (1987).
Alvarez et al., “Photocleavable Protecting Groups as Nucleobase Protections Allowed the Solid-Phase Synthesis of Base-Sensitive SATE-Prooligonucleotides”J. Org. Chem.64: 6319-6328 (1999).
Anderson et al. “A Comparison of Selected mRNA and Protein Abundances in Human Liver”Electrophiresis18: 533-537 (1997).
Arap et al., “Steps Toward Mapping the Human Vasculature by Phage Display”Nat. Med.8(2) 121-127 (2002).
Arnold et al., “Directed Evolution of Biocaatalysts”Curr. Opin. Chem. Biol.3: 54-59 (1999).
Arnold et al., “Design by Directed Evolution”Acc. Chem. Res.31: 125-131 (1998).
Bain et al. “Ribosome-Mediated Incorporation of a Non-Standard Amino Acid into a Peptide Through Expansion of the Genetic Code”Nature356: 537-539 (1992).
Baldwin et al. “Enzymes in Synthetic Organic Chemistry”Tetrahedron Organic Chemistry Series12: 1-40.
Ban et al., “The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 {dot over (A)} Resolution”Science289: 905-920 (2000).
Bannwarth et al., “A Simple and Effective Chemical Phosphyorylation Procedure for Biomolecules”Helv. Chim. Acta70: 175-186 (1987).
Barbas et al.,Chem. Int. Ed.vol. 37, 1998. 2872-2875 Benner Reviews.
Becker et al., “Synthesis, Sar and In Vivo Activity of Novel Thienopyridine Sylfonamide Pyrrolidinones as Factor Za Inhibitors”Bioorg. Med. Chem. Lett.9: 2753-

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