Surgery – Truss – Pad
Patent
1992-05-01
1994-04-19
Smith, Ruth S.
Surgery
Truss
Pad
A61B 5055
Patent
active
053037057
ABSTRACT:
A system and method of Evoked Sodium Magnetic Resonance Imaging (ESMRI) for three-dimensional localization and measurement of sodium currents in the brain during neuronal activity is disclosed. The system measures neuronal activity in response to a stimulus. The sodium MRI measures changes in the sodium concentration due to the influx of sodium into neurons during the generation of synaptic and action potentials. The system measures primarily extracellular sodium which is distinguished from intracellular sodium on the basis of different spin-spin relaxation rates (T2) for these two compartments. Repeated measurements of sodium concentrations are used to produce and display the changes in concentration cinematically. The technique of the present invention is noninvasive and produces three-dimensional brain images with sufficient spatial and temporal resolution to allow three-dimensional visualization of the sequence of neuronal activation in the brain during processing of sensory, motor, cognitive and other tasks.
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