Everninomicin biosynthetic genes

Details Everninomicin biosynthetic genes Everninomicin biosynthetic genes

2011-05-24

2011-05-24

Raghu, Ganapathirama (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S183000, C435S069100, C435S091100, C435S320100, C435S252300, C424S130100, C424S146100, C536S023100, C536S023200

Reexamination Certificate

active

07947480

ABSTRACT:
This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin biosynthetic genes, which provide the machinery for producing everninomicin, are provided. Thus, this invention provides the nucleic acid sequences needed to synthesize novel everninomicin-related compounds based on everninomicin, arising from modifications of the DNA sequence designed to change glycosyl and modified orsellinic acid groups contained in everninomicin. AMicromonosporasite-specific integrase gene is also provided, which can be incorporated in a vector for integration into any actinomycete, and, particularly intoMonospora. Thus, the invention further provides methods for introducing heterologous genes into an actinomycete chromosome using this particular vector.

REFERENCES:
patent: 5190870 (1993-03-01), Lipscomb et al.
patent: 5190871 (1993-03-01), Cox et al.
patent: 5741675 (1998-04-01), Friedmann et al.
patent: 6833135 (2004-12-01), Frazao Moniz Pereira et al.
patent: 7229813 (2007-06-01), Hosted et al.
patent: 350341 (1995-05-01), None
patent: 3139284 (1991-06-01), None
patent: WO 93/07904 (1993-04-01), None
patent: WO 93/13663 (1993-07-01), None
patent: WO 95/16046 (1995-06-01), None
patent: WO 97/13777 (1997-04-01), None
Altreuter and Clark, 1999, Curr. Op. Biotech. 10:130.
Baltz and Hosted, 1996, TIBTECH 14:245.
Baltz et al., 1998, Trends Microbiol. 2:76-83.
Baltz, 1990, Curr. Op. Biotech. 1:12-20.
Bao et al., 1999, J. Bacteriol 181:4690-5.
Bao W, et al,, 1999,Biochemistry. 38: 9752-9757.
Beck et al., 1990, European Journal of Biochemistry 192:487-498.
Becker A, etal., 1993,Mol Gen Genet. 241: 367-379.
Brautaset T, et al., 2000,Chem Biol. 7: 395-403.
Buttner et al., 1990, J. Bacteriol. 172:3367-78.
Cheng-Cai, 1996, Molecular Microbiology 20:9-15.
Cundliffe, 1989, Annual Review of Microbiology 43:207-33.
Distler J, et al., 1987,Nucleic Acids Res. 15: 8041-8056.
Donadio et al., 1993, Proc. Natl. Acad. Sci. U.S.A. 90:7119-23.
Fath et al., 1993, Microbial Reviews 57:995-1017.
Faust B, D Hoffmeister, et al., 2000,Microbiology. 146: 147-154.
Fernandez et al., 1996, Molecular and General Genetics 251:692-698.
Fernandez et al., 1998, Journal of Bacteriology 18:4929-4937.
Flett F, et al., 1997,FEMS Microbiol Lett. 155: 223-229.
Foster DR, 1999,Pharmacotherapy. 19: 1111-1117.
Gaisser et al., 1997, Journal of Bacteriology 179:6271-6278.
Ganguly AK, et al., 1975,J Am Chem Soc. 97: 1982-1985.
Ganguly AK, et al., 1979,J Antibiot(Tokyo). 32: 1213-1216.
Garbe TR, et al., 1994,Microbiology. 140: 133-138.
Guilfoile et al., 1991, Proc. Natl. Acad. Sci. USA 88:8553-8557.
Hanlon et at., 1997, Molecular Microbiology 23:459-71.
Hopwood, at al., 1990, Annual Review of Microbiology 24:37-66.
Hosted and Baltz, 1997, J. Bacteirol. 179:180-6.
Hung-wen et al., 1994, Annual Review of Microbiology 48:223-56.
Hutchinson CR, et al., 1993,Antonie Van Leeuwenhoek. 64: 165-176.
Hutchinson at al., 1995, Annual Review of Microbiology 49:201-238.
Ikeda H, 1999, et al.,Proc Natl Acad Sci U S A. 96: 9509-9514.
Johnson et al., 1998, Current Opinion Chem. Biol. 5:642-9.
Kim et al, 1995, J. Bacteriol. 77:1202.
Lichenstein HS, et al., 1990,Gene. 88: 81-86.
Liu and Thorson, 1994, Annu. Rev. Microbiol. 48:223.
Liu W, et al., 2000.,Antimicrob Agents Chemother. 44: 382-392.
Madduri et al., 1998, Nature Biotechnology, 16:69-74.
McNicholas et al., Abstract C-846, ICAAC, San Francisco, CA, 1999.
McNicholas PM, 2000,Antimicrob Agents Chemother. 44: 1121-1126.
Merson-Davies LA, et al., 1994,Mol Microbiol. 13: 349-355.
Mertz JL, et al., 1986,J Antibiot(Tokyo). 39: 877-887.
Ninet L, F Benazet, et al., 1974,Experientia, 30: 1270-1272.
Oh and Chater, 1997, J. Bacteriol. 179:122-7.
Olano et al., 1998, Molecular Gen. Genetics 3:299-308.
Paget E, et al., 1996,J Bacteriol. 178: 6357-6360.
Piepersberg W., et al., 1994,Crit Rev Biotechnol. 14: 251-285.
Pissowotzki K, et al., 1991,Mol Gen Genet. 231: 113-123.
Puar MS, et al., 1998,J Antibiot(Tokyo). 51: 221-224.
Rao et al., 1987, Methods in Enzymology 153:166-198.
Reynolds, Proc. Natl. Acad. Sci. USA, 1998, 95:112744.
Rodriguez E, et al., 1999,Microbiology. 145: 3109-3119.
Saitou N, et al., 1987,Mol Biol Evol. 4: 406-425.
Smith et al., 1997, FEMS Microbiol. Lett. 155:223-9.
Solenberg et al., Chem Biol, 1997, 4:195-202.
Strohl et al., 1991, J. Industr. Microbiol. 7:163.
Stutzman-Engwall KJ, et al., 1992,J Bacteriol. 174: 144-154.
Summers et al., 1997, Microbiology 143:3251-3262).
Tang L, et al., 1994, Ann. N Y Acad. Sci. 721:105-16.
Trefzer A,, et al., 1999,Nat Prod Rep. 16: 283-299.
Ueda et al., 1996, Gene 169:91-95.
van Wageningen AM, et al., 1998,Chem Biol. 5: 155-162.
Weinstein MJ, 1965,Antimicrob Agents Chemother. 5: 821-827.
Wilson et al., 1998, Gene 214:95-100.
Wohlleben et al., 1994, Acta Microbiol. Immunol. Hung 41:381-9.
Wolk CP, 1991,Proc. Natl. Acad. Sci. 88: 5355-5359.
Wright F, et al., 1992,Gene. 113: 55-65.
Ylihonko et al., 1996, Microbiology 142:1965.
Zhang et al., 1998, Molecular and General Genetics 258:26-33.
Adrian PV, et al., 2000,Antimicrob Agents Chemother. 44: 732-738.
Decker, H., (1996), FEMS Microbiology Letters 141:195-201.
Bechthold, A., (1999), Biorganic Chemistry, Diederichsen U. et al. Wiley-VCH Verlag GMBH, Weinheim, Germany, p. 313-321.
Malpartida, F., (1987), Nature, 325:818-821.
Koch, C., (1996), International Journal of Systematic Bacteriology, 46(2):383-387.
International Search Report for International Patent Application No. PCT/US01/01187; Date of Completion: Aug. 7, 2001.
Freitas-Vieira et al. (1998) Microbiology 144:3397-3406.

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