Everninomicin antibacterial derivatives, electrochemical method

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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204 73R, 536 17, 536 18, A61K 31715

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active

040270165

ABSTRACT:
Everninomicin derivatives devoid of a nitro group and having antibacterial activity are prepared by electrochemically reducing the corresponding everninomicin having a nitro function or salts thereof in an aprotic anhydrous solvent in the absence of carbon dioxide. A preferred starting compound is everninomicin D whereby is produced a product mixture of antibacterial agents identified as desevernitrose everninomicin D, everninomicin D-3, and everninomicin D-7, respectively.

REFERENCES:
patent: 3915956 (1975-10-01), Ganguly
patent: 3920629 (1975-11-01), Ganguly
patent: 3998708 (1976-12-01), Kabasakalian et al.

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