Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1991-06-26
1995-04-18
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 161, 424 165, 424 181, 424 185, 424 189, 424 9, 436 56, 436 57, 1286531, 1286534, 128654, A61B 505, A61B 600, A61K 4900, G01N 2300
Patent
active
054076536
ABSTRACT:
The present invention relates to methods for detecting the multidrug resistance phenotype in vivo and in vitro. The invention particularly relates to methods of diagnosing the multidrug resistance phenotype by imaging, particularly scintigraphic imaging, in solid tumors in vivo or in tumors and biopsies in vitro. The methods of the present invention allow the diagnosis of multidrug-resistant tumor and other multidrug-resistant phenotypes without invasive surgical methods.
REFERENCES:
patent: 4452774 (1984-06-01), Jones et al.
patent: 4837306 (1989-06-01), Ling et al.
patent: 5025020 (1991-06-01), Van Dyke
patent: 5186923 (1993-02-01), Piwnica-Worms
Herweijer, et al., "A Rapid and Sensitive Flow Cytometric Assay for the Detection of MDR Cells in Human Cancer," Invest New Drugs 7:442, Abstract 374 (1989).
Higgins, C. F. et al. Bioessays 8:111 (1988).
Ames, G. F. Ann. Rev. Biochem. 55:397 (1986).
Higgins, C. F. et al. J. Bioenerg. Biomembr. 22:571 (1990).
Hyde, S. C. et al. Nature 346:362 (1990).
Higgins, C. F. et al. Phil Trans R. Soc. Lond. B 326:353 (1990).
Gottesman, M. M. et al. J. Biol. Chem. 263:12163 (1988).
Bradley, G. et al. Biochim. Biophy. Acta. 948:87 (1988).
Juranka, P. F. et al. FASEB, J. 3:2583 (1989).
Gros, P. et al. Cell 47:371 (1986).
Chen, C. et al. Cell 47:381 (1986).
Yoshimura, A. et al. Cancer Lets. 50:45 (1990).
Efferth, Th. et al. Arzneim.-Forsch./Drug. Res. 38:1771 (1988).
Herweijer, H. et al. Invest. New. Drugs 7:442 Abstract 374 (1989).
Konen, P. L. et al. J. Histochem Cytochem 37:1141 (1989).
Gerlach, J. H. et al. Nature 324:485 (1986).
Higgins, C. F. et al. Nature 323:448 (1986).
McGrath, J. P. et al. Nature 340:400 (1989).
Skovsgaard, T. et al. Cancer Treat. Rev. 11 (Suppl A): 63 (1984).
Larsson, R. et al. Int. J. Cancer 46:67 (1990).
Brigham and Women's Hospital
Chapman Lara E.
Lovering Richard D.
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