Evaluation of substances for altering and for increasing APC res

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 8, 514 2, 435 13, 435 692, 435 696, 436 69, 530380, 530381, 530383, 530384, 424530, A01N 3718, A61K 3800, A61K 3514, C12Q 156

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058638962

ABSTRACT:
The present invention provides methods, reagents, and test kits for evaluating the effect of a test composition on APC response by employing factor Va.sup.R506Q Methods and compositions for treating patients suffering from reduced APC response are also provided.

REFERENCES:
patent: 4640834 (1987-02-01), Eibl et al.
patent: 5254532 (1993-10-01), Schwarz et al.
Thrombosis and Haemostasis, 62: 25, Abstract No. 37 (1989).
Amer et al., Thrombosis Research 57: 247-258 (1990).
Greengard et al., The Lancet 343: 1361-1362 (May 28, 1994).
Martinoli et al., Thrombosis Research 43: 253-264 (1986).
Nicolaes et al., J. Biological Chemistry 270(36): 21158-21166 (Sep. 8, 1995).
Camire et al., J. Biological Chemistry 270(35): 20794-20800 (Sep. 1, 1995).
Suzuki et al., Biochem 96: 455-460 (1984).
Schwarz et al., Blood 64(6): 1297-1300 (Dec. 1984).
Kalafatis et al., J. Biological Chemistry 270(8): 4053-4057 (Feb. 24, 1995).
Kalafatis et al., J. Biological Chemistry 269(50): 31869-31880 (Dec. 16, 1994).
Walker et al., Biochimica Et Biophysica Acta 517: 333-342 (1979).
Jenny et al., Proc. Natl. Acad. Sci. USA 84: 4846-4850 (Jul. 1987).
Suzuki et al., J. Biological Chemistry 257(11): 6556-6564 (Jun. 10, 1982).
Voorberg et al., The Lancet 343:1535-1536 (Jun. 18, 1994).
Saragovi et al., Science 253: 792-795 (Aug. 1991).
Taylor et al., J. Clin. Invest. 79: 918-925 (Mar. 1987).
Tans et al., Blood 77(12): 2641-2648 (Jun. 15, 1991).
Dreyfus et al., New England Journal of Medicine 325: 1565-1568 (Nov. 28, 1991).
Griffin et al., J. Clin. Invest., 68: 1370-1373 (Nov. 1981).
Bertina et al., Nature 369: 64-67 (May 5, 1994).
Koster et al., Lancet 342: 1503-1506 (Dec. 1993).
Dahlback et al., Proc. Natl. Acad. Sci. USA 90: 1004-1008 (Feb. 1993).
Walker, J. Biological Chemistry 256(21): 11128-11131 (1981).
Comp et al., Clin. Invest. 74(6): 2082-2088 (1984).
Kalafatis et al., J. Biological Chemistry 269(50): 31869-31880 (Dec. 16, 1994).
Solymoss et al., J. Biological Chemistry 263(29): 14884-14890 (Oct. 15, 1988).
Walker, J. Biological Chemistry 255(12): 5521-5524 (Jun. 25, 1980).
Suzuki et al., J. Biological Chemistry 258(3): 1914-1920 (Feb. 10, 1983).
Gruber et al., Blood 73(3): 639-642 (Feb. 15, 1989).
Rosing et al., J. Biological Chemistry 268(28): 21130-21136 (Oct. 5, 1993).
Esmon, J. Biological Chemistry 264(9): 4743-4746 (Mar. 25, 1989).

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