Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-04-29
2010-11-23
Cook, Lisa V (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C436S501000, C436S518000, C422S050000, C422S067000, C424S009100
Reexamination Certificate
active
07838257
ABSTRACT:
A method of evaluating conjugation between materials using imaging of time-of-flight secondary ion mass spectrometry (TOF-SIMS) according to the present invention is carried out by following the steps, a) forming a spontaneous pattern on a substrate with a mixture containing nanoparticles and a conjugation material selected from organic, bio or inorganic material, b) obtaining an ion detection pattern from the conjugation material and nanoparticles, respectively, depending on their position on the substrate by using time-of-flight secondary ion mass spectrometry, and c) determining whether the conjugation is formed between the conjugation material and nanoparticles by comparing the ion detection pattern of the conjugation material with the ion detection pattern of the nanoparticles.
REFERENCES:
patent: 2007/0249060 (2007-10-01), Kirschner et al.
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patent: 10-2005-0106323 (2005-11-01), None
H Min et al., “Probing Ligands and Biomolecules Conjugated onto Quantum Dots Using Mass Spectrometric Imaging”, Biomaterial Interfaces, AVS 54th Intl Symposium, Oct. 14, 2007.
Lee Tea Geol
Min Hyegeun
Moon Dae Won
Clark & Brody
Cook Lisa V
Korea Research Institute of Standards and Science
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