Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-12-11
1996-12-10
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 92, 424 9371, 435 724, 435 74, 435 15, 435 29, 436 63, 436 64, 436 86, 436501, G01N 33574
Patent
active
055830021
ABSTRACT:
A soluble immunosuppressive factor present in serum derived from tumor-bearing mammals, is associated with changes in TCR protein subunit levels and T-lymphocyte signal transduction pathway proteins. These changes provide a method of determining the level of immunosuppression in a mammal by determining the level of expression of at least one selected TCR subunit protein, or a protein in the T lymphocyte signal transduction pathway, and comparing the level to that found in non-immunosuppressed individuals. The method is useful to identify patients having T lymphocytes capable of activation for immunotherapy and for identifying agents which cause or reverse immunosuppression. An isolated immunosuppressive factor associated with the level of expression of the proteins is useful for suppressing the immune response, for example, in organ transplantation.
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Loeffler Cynthia M.
Longo Dan L.
Mizuguchi Hiromoto
O'Shea John J.
Ochoa Augusto C.
Regents of the University of Minnesota
Saunders David
The United States of America as represented by the Department of
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