Evaluating binding affinities by force stratification and...

Details Evaluating binding affinities by force stratification and... Evaluating binding affinities by force stratification and...

2006-06-13

2006-06-13

Le, Long V. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S006120, C435S007200, C435S287100, C435S287200, C435S287900, C436S517000, C436S518000, C436S524000, C436S807000, C073S104000, C073S105000, C356S501000

Reexamination Certificate

active

07060448

ABSTRACT:
The present invention is a method for selectively removing objects from a surface utilizing a probe. The probe is scanned over the surface utilizing a greater and greater relative amount of force so that a certain number of the objects are removed from the surface. The force required to remove the objects from the surface can be calculated utilizing Hook's law and the spring constant of the probe. After removal of the objects that have a relatively weaker binding affinity with the surface, the remaining objects can be harvested, characterized, and subjected to further study.

REFERENCES:
patent: 4728591 (1988-03-01), Clark et al.
patent: 5106729 (1992-04-01), Lindsay et al.
patent: 5138174 (1992-08-01), Tang
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5314829 (1994-05-01), Coles
patent: 5346683 (1994-09-01), Green et al.
patent: 5363697 (1994-11-01), Nakagawa
patent: 5372930 (1994-12-01), Colton et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5440122 (1995-08-01), Yasutake
patent: 5443791 (1995-08-01), Cathcart et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5445971 (1995-08-01), Rohr
patent: 5453970 (1995-09-01), Rust et al.
patent: 5467642 (1995-11-01), Hosaka et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5482601 (1996-01-01), Ohshima et al.
patent: 5514540 (1996-05-01), Teoule et al.
patent: 5514550 (1996-05-01), Findlay et al.
patent: 5519212 (1996-05-01), Elings et al.
patent: 5532128 (1996-07-01), Eggers et al.
patent: 5571639 (1996-11-01), Hubbell et al.
patent: 5601982 (1997-02-01), Sargent et al.
patent: 5604097 (1997-02-01), Brenner
patent: 5620854 (1997-04-01), Holzrichter et al.
patent: 5666190 (1997-09-01), Quate et al.
patent: 5670322 (1997-09-01), Eggers et al.
patent: 5688486 (1997-11-01), Watson et al.
patent: 5720928 (1998-02-01), Schwartz
patent: 5744305 (1998-04-01), Fodor et al.
patent: 5753088 (1998-05-01), Olk
patent: 5760300 (1998-06-01), Kajimura
patent: 5763768 (1998-06-01), Henderson et al.
patent: 5789167 (1998-08-01), Konrad
patent: 5800992 (1998-09-01), Fodor et al.
patent: 5837832 (1998-11-01), Chee et al.
patent: 5840862 (1998-11-01), Bensimon et al.
patent: 5846724 (1998-12-01), Bensimon et al.
patent: 5851769 (1998-12-01), Gray et al.
patent: 5866328 (1999-02-01), Bensimon et al.
patent: 5866434 (1999-02-01), Massey et al.
patent: 5874219 (1999-02-01), Rava et al.
patent: 5874668 (1999-02-01), Xu et al.
patent: 5958701 (1999-09-01), Green et al.
patent: 5965133 (1999-10-01), Cantor et al.
patent: 5981733 (1999-11-01), Gamble et al.
patent: 5985356 (1999-11-01), Schultz et al.
patent: 5992226 (1999-11-01), Green et al.
patent: 5993627 (1999-11-01), Anderson et al.
patent: 6004617 (1999-12-01), Schultz et al.
patent: 6024925 (2000-02-01), Little et al.
patent: 6033911 (2000-03-01), Schultz et al.
patent: 6045671 (2000-04-01), Wu et al.
patent: 6080586 (2000-06-01), Baldeschwieler et al.
patent: 6083763 (2000-07-01), Balch
patent: 6087274 (2000-07-01), Tonucci et al.
patent: 6110426 (2000-08-01), Shalon et al.
patent: 6123819 (2000-09-01), Peeters
patent: 6143574 (2000-11-01), Karlsson et al.
patent: 6146899 (2000-11-01), Porter et al.
patent: 6159742 (2000-12-01), Lieber et al.
patent: 6171797 (2001-01-01), Perbost
patent: 6180114 (2001-01-01), Yager
patent: 6200737 (2001-03-01), Walt et al.
patent: 6203814 (2001-03-01), Fisher et al.
patent: 6214552 (2001-04-01), Heroux et al.
patent: 6218122 (2001-04-01), Friend et al.
patent: 6231744 (2001-05-01), Ying et al.
patent: 6232706 (2001-05-01), Dai et al.
patent: 6239273 (2001-05-01), Pease et al.
patent: 6255469 (2001-07-01), Seeman et al.
patent: 6270946 (2001-08-01), Miller
patent: 6278231 (2001-08-01), Iwasaki et al.
patent: 6284497 (2001-09-01), Sabanayagam et al.
patent: 6287850 (2001-09-01), Besemer et al.
patent: 6289717 (2001-09-01), Thundat et al.
patent: 6309831 (2001-10-01), Goldberg et al.
patent: 6329209 (2001-12-01), Wagner et al.
patent: 6331396 (2001-12-01), Silverman
patent: 6350609 (2002-02-01), Morozov et al.
patent: 6395554 (2002-05-01), Regan et al.
patent: 6406921 (2002-06-01), Wagner et al.
patent: 6416952 (2002-07-01), Pirrung et al.
patent: 6420105 (2002-07-01), Landfield et al.
patent: 6436647 (2002-08-01), Quate et al.
patent: 6518168 (2003-02-01), Clem et al.
patent: 6573369 (2003-06-01), Henderson et al.
patent: 2002/0042081 (2002-04-01), Henderson et al.
patent: 2002/0063212 (2002-05-01), Mirkin et al.
patent: 2002/0076927 (2002-06-01), Henderson et al.
patent: 2002/0114987 (2002-08-01), Oscarsson et al.
patent: 2002/0122873 (2002-09-01), Mirkin et al.
patent: 2002/0123135 (2002-09-01), Henderson et al.
patent: 2002/0146714 (2002-10-01), Lieber et al.
patent: 2002/0172943 (2002-11-01), Henderson et al.
patent: 2002/0179434 (2002-12-01), Dai et al.
patent: 2003/0013111 (2003-01-01), Henderson et al.
patent: 06124680 (1994-05-01), None
patent: 07027771 (1995-01-01), None
patent: 08094646 (1996-04-01), None
patent: WO 92/15709 (1992-09-01), None
patent: WO 96/31775 (1996-10-01), None
patent: WO 97/06420 (1997-02-01), None
patent: WO 97/18326 (1997-05-01), None
patent: WO 98/05920 (1998-02-01), None
patent: WO 98/18959 (1998-05-01), None
patent: WO 99/31267 (1999-06-01), None
patent: WO 00/04382 (2000-01-01), None
patent: WO 00/04389 (2000-01-01), None
patent: WO 00/04390 (2000-01-01), None
patent: WO 00/36136 (2000-06-01), None
patent: WO 00/41213 (2000-07-01), None
patent: WO 00/46406 (2000-08-01), None
patent: WO 01/60316 (2001-08-01), None
patent: WO 01/918555 (2001-12-01), None
patent: WO 03/001633 (2003-01-01), None
patent: WO 03/036767 (2003-05-01), None
patent: WO 03/038033 (2003-05-01), None
patent: WO 03/048314 (2003-06-01), None
patent: WO 03/052514 (2003-06-01), None
Lee et al. Sensing discrete streptavidin-biotin interactions with atomic force microscopy. Langmuir (1994), vol. 10, pp. 354-357.
Baselt, D.R., et al., “A biosensor based on magnetoresistance technology”Biosens. Bioelectorn,1998, 13(7-8):731-739.
Florin, E., et al., “Adhesion forces between individual ligan-receptor pairs”Science,1994, 264:415-417.
Mazzola, L., “Imaging biomolecule arrays by atomic force microscopy”Biophysical Journal,1995, 68:1653-1660.
Allen, et al. “Detection of Antigen-Antibody Binding Events with the Atomic Force Microscope”Biochemistry,(1997) 36:7457-7464.
“Microbeam Mass Spectrometry”Chemical Science and Technology Laboratory, Surface and Microanalysis Science Divisionhttp://www.cstl.nist.gov/div837/Divisoin/expertise/ions/masspec1.htm Jul. 18, 2002.
Abstracts of Papers Part 1, 214th“Abstract 027”ACS National Meeting American Chemical Society,Sep. 1997, 2 pgs.
Allison, D., et al., “Direct atomic force microscopy imaging ofEcoRI endonuclease site specifically bound to plasmid DNA molecules”PNAS USA,1996, 93:8826-8829.
Allison, D., et al., “Mapping Individual Cosmid DNAs by Direct AFM Imaging”Genomics,1997, 41:379-384.
Alves, et al., Atomic scale imaging of alkanethiolate monolayers at gold surfaces with atomic force microscopy:J. Am. Chem. Soc.,Feb. 1992,114(4):1222-1227.
Amro, et al., “Patterning surfaces using tip-directed displacement and self-assembly”Langmuir,2000, 16:3006-3009.
Anwander, et al., “Surface characterization and functionalization of MCM-41 silicas via silazane silylation”J. Phys. Chem. B.,2000, 104:3532-3544.
Arntz, et al., “Label-free protein assay based on a nanomechanical cantilever array”Nanotechnology,14 (2003) 86-90.
Ausubel, F.M., et al. “Current Protocols in Molecular Biology” 1993 ed. vol. 1&2, 1993, Green Publishing Associates and Wiley-Interscience.
Avouris, P., et al., “Engineering Carbon Nanotube and Nanotubes Circuits Using Electrical Breakdown”Science,Apr. 2001, 292(5517):706-799.
Bailey, C.P., et al., “Cationic oligonucleotides can mediate specific inhibition of gene expression in Xenopus oocytes”Nuc. Acids Res.,1998, 26(21):4860-4867.
Bain, et al., “Modeling organic surfaces with self-assemble

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