Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-04-11
1997-12-16
Feisee, Lila
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
435 71, 435236, 435239, 5303883, 5303894, C12N 702, A61K 39155
Patent
active
056982038
ABSTRACT:
The present invention is concerned with European strains of the Porcine Reproductive Respiratory Syndrome (PRRS) virus, which are attenuated, and show a characteristic reaction pattern with two monoclonal antibodies against wild-type PRRSV.
The invention also relates to vaccines for the protection of pigs against PRRS, to monoclonal antibodies reactive with PRRS virus and monoclonal antibodies specifically non-reactive with the attenuated strains.
REFERENCES:
J.M.A. Pol et al., The Veterinary Quaterly, 13:3:137-143, 1991.
G. Terpstra et al., The Veterinary Quaterly, 13:3:131-136, 1991.
E. Nelson et al., "Differentiation of US and European isolates of porcine reproductive and resiratory virus by monoclonal antibodies," J. Clin. Micro., 31:12:3184-3189, 1993.
H. Mardassi et al., "Identifications of major differences in the nucleocapsid proteins of Quebec strain and European strains of PRRSV," J. Gen. Virol., 75:3:681-685, 1994.
G. Wensvoort et al., "Antigenic comparison of Lelystad virus and swine infertility and respiratory syndrome firus," J. Vet. Diagn. Invest., 4:134-138, 1992.
J. Meulenberg et al., "Lelystad virus the causative agent of porcine epidemic abortion and respiratory syndrome" Virology, 192:62-72, 1993.
Paul, WE Fundamental Immunology p. 242 Third ED. 1993.
Ohlinger Volker
Van Woensel Petrus Alphonsus Maria
Visser Nicolaas
Weiland Emilie
Akzo Nobel N.V.
Blackstone William M.
Feisee Lila
Gormley Mary E.
Reeves Julie E.
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