Eukaryotic transposable element

Details Eukaryotic transposable element Eukaryotic transposable element

1995-09-20

1998-11-24

Prouty, Rebecca E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435196, 435 691, 4351723, 530350, 536 231, 536 235, 935 9, 935 19, C07H 2104

Patent

active

058408657

ABSTRACT:
Disclosed are isolated transposable elements, or isolated DNA sequences which encode a transposase protein (or a portion of a transposase protein). The isolated transposable elements or the isolated DNA sequences being characterized by the ability to hybridize to the DNA sequence of Minos-1. The invention also relates to a purified transposase protein, or peptide fragments thereof, encoded by such DNA sequences. Such transposable are useful in methods for the stable introduction of a DNA sequence of interest into a cell. The invention further relates to transgenic animals produced by such methods. The sequence information disclosed herein is useful in the design of oligonucleotide primers which are useful for the isolation of related members of the Tc-1 family of transposable elements.

REFERENCES:
patent: 5348874 (1994-09-01), Savakis et al.
Loukeris et al. "Introduction of the transposable element Minos into the germ line of Drosophila melangaster" Proc. Natl. Acad. Sci. USA 92, 9485-9489, Oct. 1995.
Loukeris et al. "Gene transfer into the medfly, Ceratitis capitata, with Drosophila hydei transposable element" Science 270, 2002-2005, Dec. 1995.
Minos-2 DNA Sequence submitted to EMBL Data Library by Charalambos Savakis; Released by EMBL Data Library on Sep. 12, 1991.
Franz, Gerald and Savakis, Charalambos, "Minos, a new transposable element from Drosophila hydei, is a member of the Tc1-like family of transposons," Nucl. Acids Res. 19(23):6646 (1991).
Franz, Gerald et al., "Mobile Minos elements from Drosophila hydei encode a two-exon transposase with similarity to the paired DNA-binding domain," Proc. Natl. Acad. Sci. USA 91(11): 4746-4750 (1994).

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