Eukaryotic transposable element

Details Eukaryotic transposable element Eukaryotic transposable element

1998-11-18

2000-12-12

Nashed, Nashaat T.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435193, 435196, 530350, 536 231, 536 232, 536 235, C12N 912, C12N 916

Patent

active

061597171

ABSTRACT:
Disclosed are isolated transposable elements, or isolated DNA sequences which encode a transposase protein (or a portion of a transposase protein). The isolated transposable elements or the isolated DNA sequences being characterized by the ability to hybridize to the DNA sequence of Minos-1. The invention also relates to a purified transposase protein, or peptide fragments thereof, encoded by such DNA sequences. Such transposable are useful in methods for the stable introduction of a DNA sequence of interest into a cell. The invention further relates to transgenic animals produced by such methods. The sequence information disclosed herein is useful in the design of oligonucleotide primers which are useful for the isolation of related members of the Tc-1 family of transposable elements.

REFERENCES:
patent: 5348874 (1994-09-01), Savakis et al.
Loukeris, T.G. et al., "Introduction of the transposable element Minos into the germ line of Drosophila melanogaster", Proc. Natl. Acad. Sci. USA, 92:9485-9489, (Oct. 1995).
Loukeris, T.G. et al., "Gene Transfer into the Medfly, Ceratitis capitata, with a Drosophila hydei, Transposable Element", Science, 270:2002-2005 (Dec. 1995).
"D. hydei Minos transposon-like element encoding transposase", submitted to EMBL Data Library by Charalambos Savakis; Released by EMBL Data Library on Sep. 12, 1991.
Franz G., and Savakis C., "Minos, a new transposable element from Drosophilia hydei, is a member of the Tc1-like family of transposons," Nucl. Acids Res., 19(23):6646 (1991).
Franz G., et al., "Mobile Minos elements from Drosophila hydei encode a two-exon transposase with similarity to the paired DNA-binding domain," Proc. Natl. Acad. Sci. USA, 91(11):4746-4750 (1994).

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