Eukaryotic transcription protein; host cell factor

Details Eukaryotic transcription protein; host cell factor Eukaryotic transcription protein; host cell factor

1993-04-12

1995-09-26

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6, 4352401, 4352523, 4353201, 536 235, 436501, 530350, 530827, C12N 1512, C07H 2104

Patent

active

054533627

ABSTRACT:
Host Cell Factor (HCF), a eukaryotic cellular protein involved in transcription, nucleic acids encoding HCF, and methods of using HCF and HCF-encoding nucleic acids are provided. HCF activity is disclosed to comprise a collection of polypeptides encoded by a structural gene encoding a parent protein of 2039 amino acids. HCF-specific binding compounds are disclose including antibodies to HCF epitopes. Because HCF is required for the transcription of a number of vital genes such as the immediate early genes of Herpes Simplex Virus, the invention provides HCF-based methods for screening chemical libraries for regulators of viral transcription. Such regulators are used in the treatment of viral infections by modulating the transcription of certain viral genes.

REFERENCES:
patent: 4399216 (1983-08-01), Axel
A. D. Friedman et al. Nature 335(6189):452-4 Sep. 29, 1988.
Wozney, J. Meth. Enz. 182:738-751, 1990.
Matsudaira, P. MethEnz. 182:602-613, 1990.
S. Stern & W. Herr, Genes Dev. 5:2555-66, 1991.
M. Katan et al., Nucleic Acids Res. 18(23):6871-80, 1990.
T. M. Kristie & P. A. Sharp, Genes Dev. 4:2383-96, 1990.
P. Xiao & J. P. Capone, Mol. Cell. Biol. 10(9) 4974-7, Sep. 1990.

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