Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-09-08
2000-11-14
Navarro, Albert
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 5303877, 5303879, 5303888, 53038885, 5303891, 5303897, 53038826, 435226, C07K 1600, C12N 964
Patent
active
061471941
ABSTRACT:
Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5'-monophosphate dehydrogenase ("IMPDH"). Illustratively, mammalian (e.g., human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g., GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitative detection of IMPDH.
REFERENCES:
patent: 4376132 (1983-03-01), Eguchi et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4404279 (1983-09-01), Ricotti et al.
patent: 4423147 (1983-12-01), Secher et al.
patent: 5344773 (1994-09-01), Wei et al.
patent: 5665583 (1997-09-01), Collart et al.
Goding J, Monoclonal Antibodies=Principles and Practice 1983 pp. 57-97.
Holmes E, et al., Biochimica et Biophysica Acta, 364 (1974) 209-217.
Anderson J and Sartorelli A, J Biolog Chem vol. 273, No. 18 Sep. 25, pp 1762-1768, 1968.
Atkins et al., "Purification and properties of inosine monophosphate oxidoreductase from nitrogen-fixing nodules of cowpea (Vigna unguiculata L. Walp)," Arch. Biochem. Biophys., 236(2):807-814, 1985.
Boyum, "A one-stage procedure for isolation of granulocytes and lymphocytes from human blood: general sedimentation properties of white blood cells in a 1 g gravity field," Scand. J. Clin. Lab. Invet., 21(97):51-55, 1968.
Caplan et al., "Introduction of genetic material into plant cells," Science, 222:815-821, 1983.
Chirgwin et al., "Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease," Biochem., 18(24):5294-5299, 1979.
Cohen and Sadee, "Contributions of the depletions of guanine and adenine nucleotides to the toxicity of purine starvation in the mouse T lymphoma cell line," Cancer Res., 43:1587-1591, 1983.
Cohen et al., "Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells," J. Biol. Chem., 256(16):8713-8717, 1981.
Cohen, "Selection and characterization of mycophenolic acid-resistant leukemia cells," Som. Cell Mol. Genet., 13(6):627-633, 1987.
Collart and Huberman, "Amplification of the IMP dehydrogenase gene in Chinese hamster cells resistant to mycophenolic acid," Mol. Cell. Biol., 7(9):3328-3331, 1987.
Collart and Huberman, "Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs," J. Biol. Chem., 263(30):15769-15772, 1988.
Cooney et al., "A straightforward radiometric technique for measuring IMP dehydrogenase," Anal. Biochem., 130:339-345, 1983.
Davis et al., "Calcium phosphate transfection of nonadherent and adherent cells with purified plasmids," In: Basic Methods in Molecular Biology, Section 18-1, pp. 286-289, 1986.
Devereux et al., "A comprehensive set of sequence analysis programs for the VAX," Nucl. Acids Res., 12(1):387-395, 1984.
Duan and Sadee, "Distinct effects of adenine and guanine starvation on DNA synthesis associated with different pool sizes of nucleotide precursors," Cancer Res., 47:4047-4051, 1987.
Elliott et al., "Differential expression of three .alpha.-tubulin genes in Chinese hamster ovary cells," Mol. Cell. Biol., 5(1):236-241, 1985.
Feinberg and Vogelstein, "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity," Anal. Biochem., 132:6-13, 1983.
Franklin and Cook, "The inhibition of nucleic acid synthesis by mycophenolic acid," Biochem. J., 113:515-524, 1969.
Gilbert and Drabble, "Active-site modification of native and mutant forms of inosine-5'-monophosphate dehydrogenase from Escherichia coli K12," Biochem. J., 191(2):533-541, 1980.
Gilbert et al., "Inosine 5'-monophosphate dehydrogenase of Escherichia coli," Biochem. J., 183:481-494, 1979.
Heath et al., "Flavor potentiators,"In: Flavor Chemistry and Technology, AVI Publishing Co., Inc., Westport, CT, Ch. 9, pp. 318-331, 1986.
Huberman et al., "Mutagen-induced resistance to mycophenolic acid in hamster cells can be associated with increased inosine 5'-phosphate dehydrogenase activity," Proc. Natl. Acad. Sci. USA, 78(5):3151-3154, 1981.
Hupe et al., "IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid," J. Biol. Chem., 261(18):8363-8369, 1986.
Huynh et al., "Constructing and screening cDNA libraries in .lambda.gt10 and .lambda.gt11,"In: DNA Cloning: A Practical Approach, IRL Press, Oxford; Washington D.C., Glover, ed., Chapter 2, vol. 1:49-78, 1985.
Ikegami et al., "Direct assay method for inosine 5'-monophosphate dehydrogenase activity," J. Biochem., 150:155-160, 1985.
Ikegami et al., "Purification of IMP dehydrogenase from rat hepatoma 3924A," Life Sci., 40(23):2277-2282, 1987.
Itakura et al., "Synthesis and use of synthetic oligonucleotides," Ann. Rev. Biochem., 53:323-356, 1984.
Jackson et al., "Partial purification, properties and regulation of inosine 5'-phosphate dehydrogenase in normal and malignant rat tissues," Biochem. J., 166:1-10, 1977.
Jackson and Weber, "IMP dehydrogenase, an enzyme linked with proliferation and malignancy," Nature, 256:331-333, 1975.
Joye et al., Nucleic Acids Research, 11(8):2325-2335, 1983.
Kittler et al., "A general immunochemical method for detecting proteins on blots," Anal. Biochem., 137:210-216, 1984.
Klock and Bainton, "Degranulation and abnormal bactericidal function of granulocytes procured by reversible adhesion to nylon wool," Blood, 48(1):149-161, 1976.
Kozak, "Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs," Nucl. Acids Res., 12(2):857-872, 1984.
Krishnaiah, "Inosinic acid 5'-monophosphate dehydrogenase of Escherichia coli: purification by affinity chromatography and some properties," Arch. Biochem. Biophys., 170:567-575, 1975.
Laemmli, "Cleavage of structural proteins during the assembly of the head of bacteriophage T4," Nature, 227:680-685, 1970.
Maclean et al., "Introduction of novel genes into fish," Biotech., 5:257-261, 1987.
Maniatis et al., In: Molecular cloning: a laboratory manual, Cold Spring Harbor Laboratory, NY, pp. 315-321, 1982.
Messing, "New vectors for cloning genes," Meth. Enzymol., 101(2):20-78, 1983.
Miyagawa et al., "Cloning of the Bacillus Subtilis IMP dehydrogenase gene and its application to increased production of guanosine," Biotech., 4:225-228, 1986.
Natsumeda et al., "Two distinct cDNAs for human IMP dehydrogenase," J. Biol. Chem., 265(9);5292-5295, 1990.
Newman et al., "Activity of inosine monophosphate dehydrogenase inhibitors against human immunodeficiency virus," Proc. Am. Assoc. Cancer Res. Meet., 28(0):323, 1987.
Nowack and Shaw, "Mycophenolic Acid Binding to Human Serum Albumin: Characterization and Relation to Pharmacodynamics," Clin. Chem., 41(7):1011-1017, 1995.
Okado et al., "IMP dehydrogenase. II. Purification and properties of the enzyme from Yoshida sarcoma ascites tumor cells," J. Biochem., 94:1605-1613, 1983.
Okayama and Berg, "A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells," Mol Cell Biol., 3(2):280-289, 1983.
Okayama and Berg, "High-efficiency cloning of full-length cDNA," Mol. Cell. Biol., 2(2):161-170, 1982.
Old et al., "Cloning in Bacteria other than E. coli," In: Principles of Gene Manipulation: An Introduction to Genetic Engineering, Blackwell Scientific Publishers, 3rd ed., Chapter 8, pp. 10-13, 127-202, 288-293, 1985.
Palmiter et al., "Metallothionein-human GH fusion genes stimulate growth of mice," Science, 222:809-814, 1983.
Sambrook et al, "Using antibodies in immunological screening," In: Molecular cloning: a laboratory manual--2nd ed., Cold Spring Harbor Laboratory Press, 12.11-12.15, 1989.
Sanger et al., "DNA sequencing with chain-terminating inhibitors," Proc. Natl. Acad. Sci. USA, 74(12):5463-5467, 1977.
Schulz et al., "Optimizing th
Collart Frank R.
Huberman Eliezer
ARCH Development Corporation
Lee Li
Navarro Albert
LandOfFree
Eukaryotic IMPDH polynucleotide and antibody compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Eukaryotic IMPDH polynucleotide and antibody compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Eukaryotic IMPDH polynucleotide and antibody compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2066451