Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-05-06
2008-05-06
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
10415657
ABSTRACT:
The present invention relates to the significant functional role of severalC. elegansgenes and of their corresponding gene products in cell division and proliferation processes that could be identified by means of RNA-medicated interference (RNAi) and to the identification and isolation of functional orthologues of said genes including all biologically-active derivatives thereof. The invention further relates to the use of said gene products (including said orthologues) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative diseases.
REFERENCES:
patent: 5155037 (1992-10-01), Summers
patent: 5162222 (1992-11-01), Guarino et al.
patent: 6639063 (2003-10-01), Edwards et al.
patent: 0 397 485 (1990-11-01), None
Scott et al, Nature Genetics, 1999, 21:440-443).
Skolnick et al, 2000, Trends in Biotech. 18:34-39.
Bork, 2000, Genome Research 10:398-400.
Doerks et al, 1998, Trends in Genetics 14:248-250.
Smith et al, 1997, Nature Biotechnology 15:1222-1223.
Brenner, 1999, Trends in Genetics 15:132-133.
Bork et al, 1996, Trends in Genetics 12:425-427.
Bowie et al, 1990, Science 247:1306-1310.
Hitzeman et al., “Isolation and Characterization of the Yeast 3-Phosphoglycerokinase Gene (PKG) by an Immunological Screening Technique”,The Journal of Biological Chemistry(Dec. 25, 1980), vol. 255, No. 24, pp. 12073-12080.
Vasudevan et al., “Muscarinic acetylcholine receptor produced in recombinant baculovirus infected sƒ9 insect cells couples with endogenous G-proteins to activate ion channels”,FEBS(Oct. 1992), vol. 311, No. 1, pp. 7-11.
Palmiter et al., “Metallothionein-Human GH Fusion Genes Stimulate Growthh of Mice,”Science(1983), vol. 222, pp. 809-814.
Subramani et al., “Expression of the Mouse Dihydrofolate Reductase Complementary Deoxyribonucleic Acid in Simian Virus 40 Vectors”,Molecular and Cellular Biology(Sep. 1981), vol. 1, No. 9, pp. 854-864.
Russell et al., “DNA sequence of two yeast promoter-up mutants”,Nature(1983), vol. 304, pp. 652-654.
Sulston et al., “The Embryonic Cell Lineage of the NematodeCaenorhabditis elegans”, Developmental Biology(1983), vol. 100, pp. 64-119.
Sluder et al., “Control of centrosome reproduction: The right number at the right time”,Biology of the Cell(1999), vol. 91, pp. 413-427.
Database EMBL ′Online! EMBL-EBI; Jun. 23, 1998, TheC. ElegansSequencing Consortium: “Genome sequence of the nematodeC. elegans: a platform for investigating biology”, Database accession No. AL 024499, XP002199986.
Database Genbank ′Online! NCBI; Oct. 25, 2000, TheC. ElegansSequencing Consortium: “Genome sequence of the nematodec. elegans: a platform for investigating biology”, Database accession No. AL024499, XP002199987.
TheC. ElegansSequencing Consortium: Genome sequence of the nematodeC. elegans: A platform for investigating biology, Science (Washington DC), vol. 282, No. 5396, Dec. 11, 1998, pp. 2012-2018, XP002199976, ISSN: 0036-8075.
Kaitna, Susanne et al., “Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis.” Current Biology, vol. 10, No. 19, Sep. 15, 2000, pp. 1172-1181, XP002199977, ISSN: 0960-9822.
Boxem Mike et al., “TheCaenorhabditis elegansgene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase.” Development (Cambridge), vol. 126, No. 10, May 1999, pp. 2227-2239, XP002199978, ISSN: 0950-1991.
Hong Yang et al., “Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression inCaenorhabditis elegans.” Development (Cambridge), vol. 125, No. 18, 1998, pp. 3585-3597, XP002199979, ISSN: 0950-1991.
Goenczy et al., “Large-scale Screening for Genes Required for Cell Division inC. elegans.” Press Book 39. ASCB Annual Meeting Slected Biomedical Abstracts, Dec. 11-15, 1999, Washington, D.C., ′Online!, XP002199980, Retrieved from the Internet: <URL:http://www.ascb.org/meetings/am99/pressbk99.pdf>, retrieved on May 23, 2002.
Goenczy Pierre et al., “Dissection of cell divisions processed in the one cell stageCaenorhabditis elegansembryo by mutational analysis.” Journal of Cell Biology, vol. 144, No. 5, Mar. 8, 1999, pp. 927-946, XP002199981, ISSN: 0021-9525.
Fire Andrew et al., “Potent and specific genetic interference by double-stranded RNA inCaenorhabditis elegans.” Nature (London), vol. 391, No. 6669, Feb. 19, 1998, pp. 806-811, XP002199982, ISSN: 0028-0836.
Fraser Andrew et al., “Functional genomic analysis ofC. eleganschromosome I by systematic RNA interference.” Nature (London), vol. 408, No. 6810, Nov. 16, 2000, pp. 325-330, XP002199983, ISSN: 0028-0836.
Goenczy Pierre et al., “Functional genomic analysis of cell division inC. elegansusing RNAi of genes on chromosome III.” Nature (London), vol. 408, No. 6810, Nov. 16, 2000, pp. 331-336, XP002199984, ISSN: 0028-0836.
Waterson, R. “Caenorhabditis eleganscosmid C02F5, complete sequence”, Database EMBL ′Online! EBI; May 9, 1993, Database accession No. L14745, XP002212273.
Wilson et al., “2.2 Mb of contiguous nucleotide sequence from chromosome III ofC. elegans”, Nature, vol. 368, Mar. 3, 1994, pp. 32-38, XP002014926.
Waterson R., “Caenorhabditis eleganscosmid F10E9, complete sequence”, Database EMBL ′Online! EBI; Feb. 16, 1993, Database accession No. L10986, XP002212274.
Kohara Y., “C. eleganscDNA clone yk352b6: 5' end, single read.” Database EMBL ′Online!, Database accession No. C64048, XP002212275.
McCombie et al., “West00235 Mixed Stage, Stratagene (cat #937006)Caenorhabditis eleganscDNA clone CEMS47, mRNA sequence.” Database EMBL ′Online! EBI; Aug. 16, 1997, Database accession No. M79698, XP002212276.
Mas et al., “Cloning and expression analysis of a novel gene, RP42, mapping to an autisn susceptibility locus on 6g16”, Database EMBL ′Online! EMBL-EBI; Aug. 17, 2000, Database accession No. AF292100, XP002199988, & Genomics, vol. 65, Apr. 1, 2000, pp. 70-74, XP002199985..
Khelfaoui Malik et al., “Early neuronal and glial determination from mouse E10.5 telencephalaon embryonic stem cells: An in vitro study.” NEUROREPORT, vol. 13, No. 9, 2002, pp. 1209-1214, XP001095765, Jul. 2, 2002, ISSN: 0959-4965.
Echeverri Christophe
Goenczy Pierre
Hyman Anthony
Jones Steven
Kirkham Matthew
Cenix Bioscience GmbH
Foley & Lardner LLP
Halvorson Mark
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