Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1987-02-03
1990-03-27
Martinell, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 435 91, 4351721, 4351723, 4352401, 4352402, 4352404, 4352523, 435320, 536 27, 935 11, 935 32, 935 34, 935 61, 935 67, 935 68, 935 69, 935 70, C12P 2100, C12P 2102, C12P 2104, C12P 1934, C12N 1500, C12N 500, C12N 502, C12N 120, C07H 2104
Patent
active
049120409
ABSTRACT:
This invention provides vectors, improved host cells and improved methods for producing a heterologous protein by culturing an improved eucaryotic host cell of this invention transformed or transfected with a vector capable of directing the expression of the heterologous protein. The preferred improved host cell of this invention is a mammalian host cell containing and capable of expressing an anti-sense GRP78 DNA sequence.
REFERENCES:
Izant et al.; Science 229: 346 (1985).
Lee et al.: J. Biolo. Chem. 258: 597 (1983).
Lin et al.: Mol. Cell. Biol. 6: 1235 (1986).
Attenello et al.; Science 226: 187 (1984).
Toole et al.; Nature 312: 342 (1984).
Dorner Andrew
Kaufman Randal J.
Berstein David L.
Eisen Bruce M.
Genetics Institute Inc.
Martinell James
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