Eubacterial tmRNA sequences and uses thereof

Details Eubacterial tmRNA sequences and uses thereof Eubacterial tmRNA sequences and uses thereof

2011-02-15

2011-02-15

Epps-Smith, Janet (Department: 1633)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200, C514S04400A, C536S023100, C536S023700

Reexamination Certificate

active

07888029

ABSTRACT:
The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays.

REFERENCES:
patent: 5861245 (1999-01-01), McClelland et al.
Genbank Accession No. U68080, Williams et al. Feb. 26, 1997.
B. Felden et al., “Eubacterial tmRNAs: everywhere except the alpha-Proteobacteria?”Biochimica et Biophysica Acta 1446:145-148, 1999.
N. Nameki et al., “Three of four pseudoknots in tmRNA are interchangeable and are substitutable with single-stranded RNAs,” FEBS Lett 470(3):345-349, Mar. 31, 2000.
N. Nameki et al., “Functional and structural analysis of a pseudoknot upstream of the tag-encoded sequence inE. colitmRNA,” J. Mol. Biol 286(3):733-744, Feb. 26, 1999.
W. Schönhuber et al., “Utilization of tmRNA squences for bacterial identification,” MBC Microbiology 2001, 1:20 (online, 8 pages).
K.P. Williams et al., “Phylogenetic analysis of tmRNA secondary structure,” RNA 2:1306-1310, 1996.
C. Zwieb et al., “Survey and Summary, Comparative sequence analysis of tmRNA,” Nucleic Acids Research 27(10):2063-2071, 1999.
Huang, C. et al., “Charged tmRNA but not tmRNA-mediated proteolysis is essential forNeisseria gonorrhoeaeviability,” The EMBO Journal, vol. 19, No. 5, pp. 1098-1107, 2000, copyright European Molecular Biology Organization.
Ley, B.E. et al., “Eubacterial approach to the diagnosis of bacterial infection,” Archives of Disease in Childhood 1997;77:148-149.

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