Etoposide solution in NMP

Details Etoposide solution in NMP Etoposide solution in NMP

1986-10-29

1988-09-20

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 25, 514 27, 536 181, 424455, A61K 966, A61K 942, C07H 1520, C07H 1524

Patent

active

047725893

ABSTRACT:
A stable solution of etoposide in 1-methyl-2-pyrrolidinone is disclosed. The solution can be diluted with a parenteral vehicle to yield an infusion solution containing up to 10 mg/ml etoposide activity without rapid etoposide crystallization. Solutions having etoposide concentration of as high as 500 mg/ml can also be prepared and used to fill gelatin capsules.

REFERENCES:
patent: 4540564 (1985-09-01), Bodor
patent: 4547567 (1985-10-01), Umezawa et al.
patent: 4701327 (1987-10-01), Henmi et al.
patent: 4713246 (1987-12-01), Begum et al.
patent: 4716221 (1987-12-01), Umezawa et al.
Physician's Desk Reference, 40th Ed., pp. 725-727.
D. J. Stewart, Cancer Treat Rep., 69:269-273, 1985.

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