Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1992-11-09
1997-03-11
Naff, David M.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435822, 435366, C12N 120, C12N 500
Patent
active
056100590
ABSTRACT:
A novel intracellular organism isolated from enterocytes of pigs affected by Porcine Proliferative Enteritis (PPE) may be cultured by passage in a permissive host cell and may be purified from lysates of such cells. On inoculation, the organism of the present invention causes PPE-like symptoms in pigs. The infectious PPE-causing agent may be used to develop a whole organism bacterin or subunit preparation effective to prevent PPE. In addition, the cultured isolate may be used to prepare a battery of therapeutic and diagnostic monoclonal antibodies directed against the PPE-causing agent. Further, by isolating the genetic material from the agent, various useful fusion proteins may be prepared and the genetic makeup of the organism may be determined.
REFERENCES:
patent: 5110589 (1992-05-01), Joens et al.
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McOrist, S., et al., "Infection & Immunity." vol. 57, #3, Mar. 1989, pp. 957-962.
Gebhart, C. J., et al., "J. of Clin. Microbio.," vol. 29, #5, May 1991, pp. 1011-1015.
Lomax et al Am J Vet Res 43(9) Sep. 1982 pp. 1622-1630.
Mapother, M.E., L.A. Joens, and R.D. Glock. 1987. Experimental reproduction of porcine proliferative enteritis (PPE). Vet. Rec. 121:533-536.
Rowland, A.C. and G.H.K. Lawson. Diseases of Swine. Ed. Lehman, 1986. 6th Edit. Intestinal adenomatosis complex (Porcine proliferative enteropathies). Iowa State Press, pp. 547-556. Section 4, Chap. 47.
Yates, W.D.G., E.G. Clark, A.D. Osborne, C.C. Enweani, O.M. Radostits and A. Theede. 1979. Proliferative hemorrhagic enteropathy in swine: An out-break and review of the literature. Am. Vet J., vol. 20. pp. 261-268.
Glock Robert D.
Joens Lynn A.
Larson Kristin K.
Naff David M.
University of Arizona
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