Ethynylheteroaromatic-acids having retinoic acid-like activity

Details Ethynylheteroaromatic-acids having retinoic acid-like activity Ethynylheteroaromatic-acids having retinoic acid-like activity

1989-01-30

1990-05-22

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549483, 549486, 549487, 549497, 549498, 549499, 549505, 549 70, 549 71, 549 72, 549 78, 549 79, 549 80, 544224, 544242, 544335, 544336, 544407, 544410, C07D30702, C07D23702, C07D24102

Patent

active

049279475

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## wherein A is pyridyl, furyl, thienyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH and its esters, amides and pharmaceutically acceptable salts, --CHO and its acetal derivatives, --COR.sub.1 and its ketal derivatives where R.sub.1 is --(CH.sub.2).sub.n CH.sub.3 where n is defined above, or --CH.sub.2 OH and its ether and acyl ester derivatives; or a pharmaceutically acceptable salt.

REFERENCES:
Dawson et al., J. Med. Chem., 26, 1282-1293 (1983).

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