Ethynylheteroaromatic-acids having retinoic acid-like activity

Details Ethynylheteroaromatic-acids having retinoic acid-like activity Ethynylheteroaromatic-acids having retinoic acid-like activity

1990-03-13

1990-12-25

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 70, 549 72, 549 79, 549 80, C07D33322, C07D33338, C07D33308, C07D33324

Patent

active

049804847

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## wherein A is pyridyl, furyl, thienyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH and its esters, amides and pharmaceutically acceptable salts, --CHO and its acetal derivatives, --COR.sub.1 and its ketal derivatives where R.sub.1 is --(CH.sub.2).sub.n CH.sub.3 where n is defined above, or --CH.sub.2 OH and its ether and acyl ester derivatives; or a pharmaceutically acceptable salt.

REFERENCES:
patent: 4847288 (1989-07-01), McCarthy et al.

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