Ethynylation of 16-methyl-17-keto steroids

Details Ethynylation of 16-methyl-17-keto steroids Ethynylation of 16-methyl-17-keto steroids

1984-04-26

1986-10-21

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, 540 87, 540 88, 540118, C07J 100

Patent

active

046184562

ABSTRACT:
The process of the present invention transforms 16.alpha.- or 16.beta.-methyl-17-keto steroids (I) to the corresponding 17.alpha.-ethynyl-17.beta.-hydroxy-16.alpha.- or 16.beta.-methyl steroids (II) without epimerization and loss of stereochemistry of the 16.alpha.- or 16.beta.-methyl group.

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