Ethyleneimine inactivated organisms

Details Ethyleneimine inactivated organisms Ethyleneimine inactivated organisms

1975-09-26

1977-11-15

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3902

Patent

active

040585999

ABSTRACT:
Microorganisms can be rendered inactive without impairing their antigenicity or immunogenicity by treating the microorganisms with ethyleneimine. The microorganism is placed in a suspension containing ethyleneimine up to a final concentration of 0.005 to 2% V/V. The temperature of the ethyleneimine-containing suspension is maintained between 0.degree. and 45.degree. C for between a few hours and 2 days. The excess ethyleneimine is destroyed.

REFERENCES:
patent: 3318775 (1967-05-01), Melvin et al.
patent: 3487157 (1969-12-01), Pierce
patent: 3636196 (1972-01-01), Bauer et al.
Walpole et al., Brit. J. Pharmacol. 9:306-(1954) The Carcinogenic Actions of Some Monofunctional Ethyleneimine Derivatives.
Hoffman "Toxic Gases" Chap. 4 Hugo (1971) Inhibition and Destruction of the Microbial Cell.
Chem. Abst. 80 #13568t (1974) of Ger. Offen. 2315563 Oct. 11, 1973 Penn et al.
Chem. Abst. 70 #40617h (1969) of Phillips C. R. Gaseous Sterilization.
Chem. Abst. 44 #6577d-6578e (1950) of Phillips; C. R. et al.
Phillips Bact. Rev. 16:135-138 (1952) "Relative Resistance of Bacterial Spores and Vegetative Bacteria to Disinfectants".

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