Ethyleneimine inactivated microorganisms

Details Ethyleneimine inactivated microorganisms Ethyleneimine inactivated microorganisms

1975-09-26

1977-07-19

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

195 14, A61K 3912

Patent

active

040369528

ABSTRACT:
Microorganisms can be rendered inactive without impairing their antigenicity or immunogenicity by treating the microorganisms with ethyleneimine. The microorganism is placed in a suspension containing ethyleneimine up to a final concentration of 0.005% to 2% V/V. The temperature of the ethyleneimine-containing suspension is maintained between 0.degree. C and 45.degree. C for between a few hours and 2 days. The excess ethyleneimine is destroyed.

REFERENCES:
patent: 3318775 (1967-05-01), Melvin et al.
patent: 3636196 (1972-01-01), Bauer et al.
Walpole et al., Brit. J. Pharmacol g: 306-323 (1954) "The Carcinogenic Actions of Some Monofunctional Ethyleneimine Derivatives".
Brown et al., Chem. Abst. 60, No. 6064c (1964) abst. of "The Use of Acetylethylenimine in the Production of Inactivated Foot-and-Mouth Disease Vaccines "J. Hyg. 61: 337-344, (1963).
Phillips, C. R., Chem. Abst. 70, No. 40617h (1969) abst. of "Gaseous Sterilization" U.S. Clearinghouse Fed. Sci. Tech. Inform, (1968), ad-671373, p. 17.
Bauer, K., Chem. Abst. 73, No. 32703e (1970) abst. of "Inactivation of Foot and Mouth Disease Virus by Ethylethylenimine and the Use of the Inactivated Virus in the Preparation of Vaccines" Zentralbl. Bakteriol. Parasitonk. Infektion Skr. Hyg. Abt. 1: Orig (1970) 213(3): 285-297.
Hoffman, R. K., "Toxic Gases" Chap. 4, pp. 254-255, "Inhibition and Destruction of the Microbial Cell" Hugo, Ed., Academic Press, N.Y. (1971).
Vorontsova, T. V., Chem. Abst. 76, No. 539b (1972) abst. of "Induction of S-Mutation in Fowl Plague Virus by Ethylenimine" Vop. Virusol. (1971), 16(4): pp. 416-421.
Cunliffe, H. R., Applied Microbiology 26(5): 747-750, Nov. 1973, "Inactivation of Foot-and-Mouth Disease Virus with Ethylenimine".
Warrington, R. E. et al., Am. J. Vet. Res. 34(8): 1087-1091, Aug. 1973, "Derivatives of Aziridine as Inactivants for Foot-and-Mouth Disease Virus Vaccines".

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