Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes

Details Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes

1978-03-21

1980-06-10

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1906, C07H 1910, C07F 1500

Patent

active

042074169

ABSTRACT:
Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes are characterized by high anti-tumor activity and low mammalian toxicity.

REFERENCES:
patent: 4080324 (1978-03-01), Hoeschele
Cleare et al., Coordination Chemistry Reviews, vol. 12, pp. 349 and 399-405, Jun. 1974.
Connors et al., Platinum Coordin. Complexes in Cancer Chemother., title pp. IX, XI, XII, 40-41, 51-52, 61, 66, 84-89, 135 and list of participants (Jun. 1974).
Rosenberg, Die Naturwissenschaften, vol. 60, pp. 399-406 (1973).
Gelaman et al., Russian J. of Inorganic Chemistry, vol. 5, p. 1602 (1970).
Mansy et al., J. Am. Chem. Soc., vol. 95, pp. 1633-1646 (1973).

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