Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinu

Details Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinu Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinu

1979-03-07

1980-11-18

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424287, C07F 1500

Patent

active

042345006

ABSTRACT:
Ethylenediamine platinum(II) and 1,2-diaminocyclohexane platinum(II) pyrophosphate complexes are prepared by reaction of the appropriate diaquo platinum(II) salt with a pyrophosphate salt. These complexes possess pronounced anti-tumor activity and low toxicity and thus have high therapeutic indices.

REFERENCES:
patent: 4115418 (1978-09-01), Gale et al.
patent: 4140707 (1979-02-01), Cleare et al.
Cleare, Platinum Coordination Complexes in Cancer Chemotherapy, Springer-Verlag, N.Y. pp. 24 to 26 (1974).
Schwartz et al., Cancer Treatment Rep. 61, pp. 1519-1525, (1977).
Cleare et al., Bioinorganic Chemistry 2, pp. 196-200 (1973).
Leh et al., J. of Pharmaceutical Sciences, 65 (No. 3), pp. 319-320 (1976).

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