Ethylenediamine derivatives of aryloxypropanolamine aryl esters

Details Ethylenediamine derivatives of aryloxypropanolamine aryl esters Ethylenediamine derivatives of aryloxypropanolamine aryl esters

1983-07-15

1985-12-03

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514352, 546297, 546300, 546304, 546306, C07D21374, A61K 3144

Patent

active

045566682

ABSTRACT:
Described herein are compounds of the formula ##STR1## wherein R.sub.1 is alkyl of from 1 to about 5 carbon atoms, alkenyl of from 2 to about 5 carbon atoms, alkynyl of from 3 to about 5 carbon atoms, cycloalkyl of from 3 to about 7 carbon atoms, alkylcarboxymethyl wherein the alkyl portion is from 1 to about 5 carbon atoms, arylcarboxymethyl wherein the aryl portion is from 6 to about 10 carbon atoms, aryl of from 6 to about 10 carbon atoms, or aralkyl wherein the alkyl portion is from 1 to about 5 carbon atoms and the aryl portion is from about 6 to about 10 carbon atoms; R.sub.2 and R.sub.3 are independently hydrogen or alkyl of from 1 to about 3 carbon atoms; X is alkyl of from 1 to about 4 carbon atoms, alkenyl of from 2 to about 4 carbon atoms, alkynyl of 3 or 4 carbon atoms, alkoxy of from 1 to about 4 carbon atoms, hydroxyalkyl of from 1 to about 4 carbon atoms, alkylamino of from 1 to about 4 carbon atoms, halogen, amino, nitro, hydroxy, acetamido, or cyano; m is an integer from 0 to about 3, A is a direct bond, alkylene of from 1 to about 5 carbon atoms, or alkenylene of from 2 to about 5 carbon atoms, Y is alkyl of from 1 to about 4 carbon atoms, alkenyl of from 2 to about 4 carbon atoms, alkynyl of 3 or 4 carbon atoms, alkoxy of from 1 to about 4 carbon atoms, hydroxyalkyl of from 1 to about 4 carbon atoms, alkylamino of from 1 to about 4 carbon atoms, halogen, amino, nitro, hydroxy, acetamido, or cyano; n is an integer from 0 to about 3; and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4356322 (1982-10-01), Lehmann et al.
patent: 4387103 (1983-06-01), Erhardt et al.
March, Advanced Organic Chemistry, Reactions, Mechanisms and Structure, Second Edition, pp. 459-463, McGraw Hill Pub.

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