Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-03-20
2007-03-20
Seaman, D. Margaret (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S302000, C514S303000, C514S248000, C514S414000, C514S416000, C544S235000, C544S236000, C544S278000, C548S113000, C548S114000, C548S115000, C548S117000, C548S118000, C549S454000
Reexamination Certificate
active
10240725
ABSTRACT:
The invention relates a compound represented by the formula (1):in-line-formulae description="In-line Formulae" end="lead"?Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4 (1)in-line-formulae description="In-line Formulae" end="tail"?wherein R1and R2represent H or the like; Q1represents an aromatic ring, heterocyclic ring or the like; Q2represents a single bond, aromatic ring, heterocyclic ring or the like; Q3represents a groupor the like, Q4represents an aromatic ring, heterocyclic ring or the like; and T1represents —CO— or —SO2—, and a medicine which comprises the compound and is useful for thrombosis and embolism.
REFERENCES:
patent: 5668159 (1997-09-01), Jin et al.
patent: 5707994 (1998-01-01), Ikeda et al.
patent: 5811441 (1998-09-01), Olson et al.
patent: 5849736 (1998-12-01), Wityak et al.
patent: 5852045 (1998-12-01), Askew et al.
patent: 6300330 (2001-10-01), Stocker et al.
patent: 6359134 (2002-03-01), Tawada et al.
patent: 6525042 (2003-02-01), Kobayashi et al.
patent: 6747023 (2004-06-01), Kobayashi et al.
patent: 0 937 711 (1999-08-01), None
patent: 0 937 723 (1999-08-01), None
patent: 1 102 766 (2001-05-01), None
patent: 6-174919 (1994-06-01), None
patent: 2000-86659 (2000-03-01), None
patent: 2000-086659 (2000-03-01), None
patent: 2000-302765 (2000-10-01), None
patent: 2001-11071 (2001-01-01), None
patent: WO 93/10022 (1993-05-01), None
patent: 93/16038 (1993-08-01), None
patent: 94/20062 (1994-09-01), None
patent: WO 94/21599 (1994-09-01), None
patent: 95/11228 (1995-04-01), None
patent: 95/18111 (1995-07-01), None
patent: WO 96/10022 (1996-04-01), None
patent: 96/26187 (1996-08-01), None
patent: WO 96/26187 (1996-08-01), None
patent: WO 96/31501 (1996-10-01), None
patent: 96/37482 (1996-11-01), None
patent: 96/38426 (1996-12-01), None
patent: WO 96/40100 (1996-12-01), None
patent: WO 97/06802 (1997-02-01), None
patent: 97/14417 (1997-04-01), None
patent: WO 97/29104 (1997-08-01), None
patent: WO 97/38984 (1997-10-01), None
patent: 97/48395 (1997-12-01), None
patent: 98/6707 (1998-02-01), None
patent: WO 98/06705 (1998-02-01), None
patent: WO 98/21188 (1998-05-01), None
patent: WO 96/35956 (1998-08-01), None
patent: WO 98/35956 (1998-08-01), None
patent: 98/45262 (1998-10-01), None
patent: 98/46599 (1998-10-01), None
patent: WO 98/54164 (1998-12-01), None
patent: 98/57952 (1998-12-01), None
patent: WO 99/00121 (1999-01-01), None
patent: WO 99/00126 (1999-01-01), None
patent: WO 99/00127 (1999-01-01), None
patent: WO 99/06371 (1999-02-01), None
patent: WO 99/09027 (1999-02-01), None
patent: WO 99/16747 (1999-04-01), None
patent: 99/20606 (1999-04-01), None
patent: WO 99/20606 (1999-04-01), None
patent: 99/45939 (1999-09-01), None
patent: WO 99/57099 (1999-11-01), None
patent: WO 99/57112 (1999-11-01), None
patent: WO 99/57113 (1999-11-01), None
patent: 00/4001 (2000-01-01), None
patent: WO 00/06570 (2000-02-01), None
patent: 00/6570 (2000-02-01), None
patent: WO 00/09480 (2000-02-01), None
patent: 00/35900 (2000-06-01), None
patent: WO 00/39092 (2000-07-01), None
patent: WO 00/39111 (2000-07-01), None
patent: WO 00/39117 (2000-07-01), None
patent: WO 00/39118 (2000-07-01), None
patent: WO 00/47573 (2000-08-01), None
patent: 00/53264 (2000-09-01), None
patent: 00/59913 (2000-10-01), None
patent: WO 00/71516 (2000-11-01), None
patent: WO 00/76971 (2000-12-01), None
patent: WO 00/78749 (2000-12-01), None
patent: WO 01/17990 (2001-03-01), None
patent: WO 01/19788 (2001-03-01), None
patent: WO 01/19795 (2001-03-01), None
patent: WO 01/19798 (2001-03-01), None
patent: 01/27090 (2001-04-01), None
patent: WO 01/38309 (2001-05-01), None
patent: WO 01/64642 (2001-09-01), None
patent: WO 01/64643 (2001-09-01), None
patent: WO 02/02519 (2002-01-01), None
patent: 03/000657 (2002-03-01), None
patent: WO 02/26712 (2002-04-01), None
patent: WO 02/26720 (2002-04-01), None
patent: WO 02/26734 (2002-04-01), None
patent: WO 02/42270 (2002-05-01), None
patent: 03/000680 (2002-06-01), None
patent: 03/16302 (2002-08-01), None
patent: WO 02/060859 (2002-08-01), None
patent: WO 02/079145 (2002-10-01), None
patent: WO 02/102380 (2002-12-01), None
patent: WO 03/026652 (2003-04-01), None
patent: WO 03/045912 (2003-06-01), None
patent: WO 03/048081 (2003-06-01), None
patent: WO 03/048158 (2003-06-01), None
Chemical Abstracts, vol. 129, Abstract No. 275469 RN=213460-06-1, etc., J. Org. Chem., vol. 63, No. 20, pp. 6762-6763 1998.
Tetrahedron Letters, vol. 39, No. 13, pp. 1713-1716 RN=205495-66-6 1998.
J. Am. Chem. Soc., vol. 119, No. 6, pp. 1484-1485 RN=187458-11-3 1997.
Tetrahedron Letters, vol. 37, No. 45, pp. 8165-8168 RN=183891-95-4, 183-97-6 1996.
J. Chromatogr., A, vol. 724, No. 1-2, pp. 79-90 RN=16191-60-6 Jun. 24, 1994.
J. Med. Chem., vol. 36, No. 23, pp. 3526-3532 RN=151227-27-9, 151226-77-6 1993.
J. Med. Chem., vol. 18, No. 11, pp. 1088-1094 RN=57154-72-0 1975.
Abstracts of Papers, Part 1, 218thACS National Meeting, 0-8412-3685-2, Medi 29 and Medi 199, 3 pages, Aug. 22-26, 1999.
Abstracts of Papers, Part 2, 219thACS National Meeting 0-8412-3731-X, Medi 187, 2 pages, Mar. 26-30, 2000.
Abstracts of Papers, Part 1, 220thACS National Meeting, 0-8412-3749-2, Medi 289 and Medi 328, 3 pages, Aug. 20-24, 2000.
Abstracts of Papers, Part 2, 221stACS National Meeting, 0-8412-3788-3, Medi 128 (with poster), 3 pages, Apr. 1-5, 2001.
Abstracts of Papers, Part 2, 226thACS National Meeting, 0-8412-3889-8, Medi 79 (with poster), 3 pages, Sep. 7-11, 2003.
S. M. Sheehan, et al., Bioorganic & Medicinal Chemistry Letters, vol. 13, pp. 2255-2259, “A Four Component Coupling Stategy for the Synthesis of D-Phenylglycinamide-Derived Non-Covalent Factor Xa Medi 289INHIBITORS”, 2003.
Y. K. Yee, et al., J. Med. Chem., vol. 43, No. 5, pp. 873-882, “N2-Aroylanthranilamide Inhibitores of Human Factor Xa”, 2000.
D. K. Herron, et al., J. Med. Chem., vol. 43, No. 5, pp. 859-872, “1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa”, 2000.
C. Wu, et al., Bioorganic & Medicinal Chemistry, vol. 5, No. 10, pp. 1925-1934, “Stereochemical Influence on the Stability of Radio-Metal Complexes In Vivo. Synthesis and Evaluation of the Four Stereoisomers of 2-(p-Nitrobenzyl)-Trans-CyDTPA”, 1997.
Y.-L. Chou, et al., Bioorganic & Medicinal Chemistry Letters, vol. 13, pp. 507-511, “Structure-Activity Relationships of Substituted Benzothiophene-Anthranilamide Factor Xa Inhibitors”, 2003.
M. Adler, et al., Biochemistry, vol. 41, No. 52, pp. 15514-15523, “Crystal Structures of Two Potent Nonamidine Inhibitors Bound to Factors Xa”, 2000.
J. J. Masters, et al., J. Med. Chem., vol. 43, No. 11, pp. 2087-2092, “Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potenet Anticoagulant and Antithrombotic Activity”, 2000.
M. R. Wiley, et al., J. Med. Chem., vol. 43, No. 5, pp. 883-899, “Structure-Based Design of Potent, Amidine-Derived Inhibitors of Factor XA: Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity”, 2000.
Chemical Abstracts, vol. 129, Abstract No. 275469, RN=213460-06-1, etc., J. ORG. CHEM., vol. 63, No. 20, pages 6762-6763.
Tetrahedron Letters, vol. 39, No. 13, pages 1713-1716.
J. Am. Chem. Soc., vol. 119, No. 6, pages 1484-1485.
Tetrahedron Letters, vol. 37, No. 45, pages 6165-8168.
J. Chromatogr., A, vol. 724, No. 1-2, pages 79-90.
J. Med, Chem., vol. 36, No. 23, pages 3526-3532 RN=151227-27-9, 151226-77-6 1993.
J. Med. Chem., vol. 18, No. 11, pages 1088-1094 RN=57154-72-0.
U.S. Appl. No. 10/481,629, filed Dec. 22, 2003, Ohta, et al.
U.S. Appl. No. 10/481,262, filed Dec. 19, 2003, Ohta et al.
U.S. Appl. No. 10/240,725, filed Jul. 30, 2003, Yoshino et al., et al.
U.S. Appl. No. 10/733,344, filed Feb. 9, 2004, Ohta, et al.
U.S. Appl. No. 09/762,888, filed Feb. 12, 2001, Kobayashi, et al.
U.S. Appl. No. 10/240,725, filed Oct. 7, 2002, Yoshino, et al.
U.S. Appl. No. 10/240,725, filed Jul. 30, 2003, Yoshino, et al.
U.S. Appl. No. 10/539,995, filed Jun. 22, 2005, Nakamoto, et al.
U.S. Appl. No. 10/540,259, fil
Haginoya Noriyasu
Kanno Hideyuki
Nagamochi Masatoshi
Nagata Tsutomu
Yoshikawa Kenji
Daiichi Pharmaceutical Co. Ltd.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Seaman D. Margaret
LandOfFree
Ethylenediamine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ethylenediamine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ethylenediamine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3783197