Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-06-28
2011-06-28
Fetterolf, Brandon J (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S645000
Reexamination Certificate
active
07968533
ABSTRACT:
The present invention provides compositions comprising a gas and a gastrointestinal smooth muscle relaxing agent comprising ethyl nitrite in a therapeutically effective amount. The present invention also provides methods of relaxing gastrointestinal smooth muscle, alleviating contraction or spasm of gastrointestinal smooth muscle to facilitate a diagnostic medical procedure and treating or preventing a gastrointestinal disorder using the compositions of the invention.
REFERENCES:
patent: 6488951 (2002-12-01), Toone et al.
patent: WO 01/17596 (2001-03-01), None
patent: WO 03/011384 (2003-02-01), None
patent: WO 03/041713 (2003-05-01), None
Furchgott, R.F. et al., “Comparison of Properties of Nitric Oxide and Endothelium-Derived Relaxing Factor: Some Cautionary Findings”,I. Endothelium-Derived Relaxing Factors and Nitric Oxide, Rubanyi GM, Vanhoutte PM (eds.), Basel, Karger, pp. 8-21 (1990).
Gryglewski, R.J. et al., “Speroxide Anion is Involved in the Breakdown of Endothelium-Derived Vascular Relaxing Factor”,Nature, 320(3):454-456 (1986).
Ignarro et al., “Endothelium-Derived Relaxing Factor Produced and Released from Artery and Vein is Nitric Oxide”,Proc. Natl. Acad. Sci. USA, 84:9265-9269 (1987).
Ignarro, L.J., “Biological Action and Properties of Endothelium-Derived Nitric Oxide Formed and Released From Artery and Vein”,Circ. Res., 65(1):1-21 (1989).
Lancaster et al., “EPR Demonstration of Iron-Nitrosyl Complex Formation by Cytotoxic Activated Macrophages”,Proc. Natl. Acad. Sci. USA, 87:1223-1227 (1990).
Organic Syntheses, Coll. vol. 2, A H Blatt ed, pp. 204-205 (1943).
Palmer et al., “Nitric Oxide Release Accounts for the Biological Activity of Endothelium-Derived Relaxing Factor”,Nature, 327:524-526 (1987).
Baillie John
Hurley Kevin P.
Reynolds James D.
Stamler Jonathan S.
Vaughan Stephen O.
Cornet Jean
Duke University
Elrifi Ivor R.
Fetterolf Brandon J
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
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