Ethers of 7-hydroxy-coumarin useful as medicaments

Details Ethers of 7-hydroxy-coumarin useful as medicaments Ethers of 7-hydroxy-coumarin useful as medicaments

1977-11-17

1979-04-24

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Virus

260326, 260 8, 260343, 260 44, 260 45, 544151, 546196, A61K 3137, C07D31116

Patent

active

041512910

ABSTRACT:
The invention provides novel esters of 7-hydroxycoumarin of the formula ##STR1## in which each of R.sub.1 and R.sub.2 represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, carboxy, carboxylate, C.sub.2 -C.sub.5 alkoxycarbonyl or nitrophenyl group, and R.sub.3 represents a hydrogen atom or a group of the formula --CH.sub.2 --Z in which Z represents a di(C.sub.1 -C.sub.4 alkyl)amino group, or a saturated heterocyclic amino radical containing 5 to 7 ring members which may contain a further heteroatom, and their pharmaceutically acceptable acid addition salts. The compounds are useful as medicaments, in particular as analgesics.

REFERENCES:
patent: 3928388 (1975-12-01), Reichenbacher
Murray et al., Tetrahedron letters, No. 3, pp. 243-244, 1970.
Theimer, Chem. Abstracts, vol. 79.
Matsubara, Chem. Abstracts, vol. 79.

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