Etherified hydroxy quinazolone compounds

Details Etherified hydroxy quinazolone compounds Etherified hydroxy quinazolone compounds

1979-03-08

1982-01-12

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544285, 544286, A61K 31505, C07D23980

Patent

active

043105270

ABSTRACT:
A compound of the formula ##STR1## in which R.sub.1 denotes optionally substituted lower alkyl which is optionally branched at the linking carbon atom, R.sub.2 represents hydrogen or lower alkanoyl and R.sub.3 is a group of the formula --R.sub.3.sup.a --(R.sub.3.sup.b).sub.n -- (Ia), in which R.sub.3.sup.a represents the radical of the formula --N(R.sub.4)-- or --O-- and R.sub.4 represents hydrogen or lower alkyl, R.sub.3.sup.b denotes the radical of the formula --CH.sub.2 -- or, if R.sub.3.sup.a represents --N(R.sub.4)--, denotes the radical of the formula --C(.dbd.O)-- and n represents nought or 1, and a group of the formula Ia, in which n represents 1, can be linked to the carbonyl group of the carbamoyl grouping either via the group R.sub.3.sup.a or the group R.sub.3.sup.b, or acid addition salts thereof, which can be used pharmaceutically can be used as beta-receptor blocking agents for the treatment of disorders in the cardiac rhythm and coronary heart diseases. These compounds also possess a cardio-stimulating action; some of them also display alpha-receptor-blocking properties.

REFERENCES:
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patent: 3763153 (1973-10-01), Krapcho et al.
patent: 3931177 (1976-01-01), Coates et al.
patent: 4140789 (1979-02-01), Jaeggi et al.
Nakagawa et al., J. Med. Chem., vol. 17, pp. 529 to 533, (1974).
Chem. Abstracts, vol. 87, abst. 152206t, (1977), (Abst. of Ger. Offen. 2,700,193 pub. 7-14-77).
Burger, Medicinal Chemistry, Second Edition, pp. 79 to 81, Interscience Publishers, Inc. NY (1960).

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