Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1976-12-16
1979-02-20
Randolph, John D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544285, 544286, 544354, 42424856, 424251, 424257, 424269, 424272, 424273B, 544 92, 544105, 548305, 260307C, 2603457R, 260465E, 26034845, 26034825, 2605705P, 2605706, 560142, 568587, 560 27, 560 29, 560254, A61K 31535, C07D26518, C07D26528
Patent
active
041407890
ABSTRACT:
A compound of the formula ##STR1## in which R.sub.1 denotes optionally substituted lower akyl which is optionally branched at the linking carbon atom, R.sub.2 represents hydrogen or lower alkanoyl and R.sub.3 is a group of the formula --R.sub.3.sup.a -(R.sub.3.sup.b).sub.n -- (Ia), in which R.sub.3.sup.1 represents the radical of the formula --N(R.sub.4)-- or --O-- and R.sub.4 represents hydrogen or lower alkyl, R.sub.3.sup.b denotes the radical of the formula --CH.sub.2 -- or, if R.sub.3.sup.a represents --N(R.sub.4)--, denotes the radical of the formula --C(.dbd.O)-- and n represents nought or 1, and a group of the formula Ia, in which n represents 1, can be linked to the carbonyl group of the carbamoyl grouping either via the group R.sub.3.sup.a or the group R.sub.3.sup.b, or acid addition salts thereof, which can be used pharmaceutically can be used as beta-receptor blocking agents for the treatment of disorders in the cardiac rhythm and coronary heart diseases. These compounds also possess a cardio-stimulating action; some of them also display alpha-receptor-blocking properties.
REFERENCES:
patent: 3686176 (1972-08-01), Stuart et al.
patent: 3763153 (1973-10-01), Krapcho et al.
patent: 3931177 (1976-01-01), Coates et al.
Nakagawa et al., J. Med. Chem., vol. 17, pp. 529-533 (1974).
Jaeggi Knut A.
Ostermayer Franz
Schroter Herbert
Ciba-Geigy Corporation
Maitner John J.
Randolph John D.
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