Etheric derivative of 4(3H)-quinazolinone and a process for prep

Details Etheric derivative of 4(3H)-quinazolinone and a process for prep Etheric derivative of 4(3H)-quinazolinone and a process for prep

1989-11-01

1990-11-27

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

568642, C07D23974

Patent

active

049736914

ABSTRACT:
An etheric derivative of 4(3H)-quinazolinone which is a fluorinated 3-[2-(4-biphenylyloxy)ethyl]-4(3H)-quinazolinone, produced by reacting said 4(3H)-quinazolinone with the corresponding fluorinated 4-(2-chloroethoxy)biphenyl, and its acid addition salts, especially the hydrochloride. This compound possesses substantially higher analgesic activity and lower acute toxicity than aminophenazone, ibuprofen, acetylosalicyclic acid and paracetamol.

REFERENCES:
patent: 3454574 (1969-07-01), Keck et al.
D. B. Reisner et al. "2,3--Dihydro--9H--Isoxazolo[3,2--b]quinzolin--9--ones and 3,4--Dihydro--(1,2)--oxazino[3,2--b]quinazolin--10(2H)--ones," Drug Res. 27(I), No. 4, pp. 766-770 (1977).

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