Ethereal monosubstitutions of monosaccharide derivatives

Details Ethereal monosubstitutions of monosaccharide derivatives Ethereal monosubstitutions of monosaccharide derivatives

1978-02-17

1980-08-19

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 18, 536120, C07H 1500

Patent

active

RE0303798

ABSTRACT:
The invention provides a novel therapeutic composition comprising a pharmaceutically acceptable carrier containing a therapeutically effective amount of an ethereal monosubstitution of a monosaccharide derivative having the general formula S--O--Y, wherein S is the residue of the monosaccharide derivative selected from the group consisting of pentoses, hexoses and heptoses as single or polysubstituted acetals, ketals or esters and Y is selected from the group consisting of cyclic monovalent nitrogen-containing organic radicals and residua and monovalent organic radicals and residua having the general formula ##STR1## wherein R.sub.1 is a divalent organic radical having a linear carbon chain length of about 1-7 carbon atoms and R.sub.2 and R.sub.3 are selected from the group consisting of --H, --OH, --SH, halogen and monovalent organic radicals and residua having a linear carbon chain length of about 1-7 carbon atoms. The invention also provides certain novel ethereal monosubstitutions of monosaccharide derivatives, of which 3-O-3'-(N',N'-dimethylamino-n-propyl)-1,2-O-isopropylidene-D-glucofuranose is an example. The novel monosaccharide derivatives show striking antiviral activity or other therapeutically valuable properties and are useful as active ingredients in the above therapeutic composition. The invention further provides a method of therapeutically treating warm-blooded animals with the aforementioned therapeutic composition and novel monosubstituted monosaccharide derivatives.

REFERENCES:
patent: 3157634 (1964-11-01), Druey et al.
patent: 3494913 (1970-02-01), Rossi
patent: 3538077 (1970-11-01), Rossi
Corbett, "Jour. Chem. Soc.", 1961, pp. 2926-2930.
Roberts et al., "Canadian Jour. of Chem.", vol. 45, 1967, pp. 261-265.
Roberts et al., "Canadian Jour. of Chem.", vol. 47, 1969, pp. 1571-1580.

Affiliated with

Also associated with

Rating

Ethereal monosubstitutions of monosaccharide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ethereal monosubstitutions of monosaccharide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ethereal monosubstitutions of monosaccharide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1421603