Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1993-07-19
1994-11-08
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424 56, 25217417, A61K 716
Patent
active
053624793
DESCRIPTION:
BRIEF SUMMARY
This invention relates to the use of special alkyl ether sulfates as a surfactant component in oral hygiene and dental care preparations.
Oral hygiene and dental care preparations are used for cleaning the teeth and the oral cavity, for eliminating unwanted halitosis and for keeping the teeth and gums in a healthy state.
These effects are achieved through the cooperation of various components of which water, surfactants, flavorings and sweeteners and also abrasives and polishes are the most important. The function of the surfactants is to ensure thorough wetting of the oral cavity and the teeth, to facilitate the removal of plaque, to disperse or solubilize the flavorings and to generate foam to a certain extent, particularly in the case of toothpastes. They should not attack the oral mucosa, should have a neutral taste, should not affect the sense of taste and should not enter into any unwanted interactions with the other components of the oral hygiene and dental care preparations.
Soaps and alkyl sulfates have long played a dominant role as surfactants for toothpastes. Whereas soaps were largely displaced by alkyl sulfates on account of their high pH value and their low foaming power, alkyl sulfates have recently fallen into disrepute on account of the increased requirements which toothpaste surfactants are having to satisfy in regard to compatibility with mucous membrane.
Although alkyl ether sulfates, for example fatty alcohol polyglycol ether sulfates, have occasionally been proposed as surfactants for toothpastes and mouthwashes and although they are distinguished from alkyl sulfates by better solubility in water and compatibility with mucous membrane, they have never been adopted for use in practice because the industrially obtainable products have a bitter taste which is unacceptable in oral hygiene and dental care preparations.
It has now been found that alkyl ether sulfates having an average content of 2 to 10 glycol ether groups, which satisfy a limited specification in regard to homolog distribution and alkyl sulfate content, ideally fulfil the taste requirements which a surfactant for oral hygiene and dental care preparations is expected to satisfy.
The present invention relates to the use of alkyl ether sulfate mixtures corresponding to formula (I) M is an alkali metal or magnesium ion and x has an average value of 2 to 10, at least 50% by weight of the mixture consisting of homologs with x-1 to x+1 glycol ether groups and the content of alkyl sulfates in which x=0 being below 10% by weight, as a surfactant component in oral hygiene and dental care preparations.
Processes for the production of narrow-range ether sulfates such as these with their reduced alkyl sulfate content have recently been developed. The starting materials used are adducts of 2 to 10 mol ethylene oxide with linear fatty alcohols containing 12 to 18 carbon atoms which have been produced by any of the known ethoxylation processes that give narrow range ethoxylates. Ethoxylation processes such as these are described, for example, in EP-A-6 105, EP-A-18 463, EP-A-20 867, EP-A-33 359, EP-A-46 582, EP-A-46 947, EP-A-82 554, EP-A-95 562 or EP-A-321 053.
A particularly preferred ethoxylation process is described in EP-A-339 426. In this process, alkyl polyglycol ether mixtures suitable as starting products for ether sulfate production are obtained by addition of 2 to 10 mol and preferably 3 to 6 mol ethylene oxide onto 1 mol of a C.sub.12-18 fatty alcohol in the presence of calcined hydrotalcites as catalysts. The alkyl polyglycol ethers are sulfated in known manner by reaction with chlorosulfonic acid or sulfur trioxide and neutralization of the sulfation product with aqueous alkali metal of magnesium hydroxide, preferably with aqueous sodium hydroxide.
The alkyl ether sulfates obtained in this way have a very low content of alkyl sulfate of less than 10% by weight, based on the anionic surfactant content. Certain amounts of unsulfated ethoxylate, usually of the order of 2 to 10% by weight of the anionic surfactant content, are
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Breitzke Willi
Gantke Karl-Heinz
Raths Hans-Christian
Tesmann Holger
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Millson Jr. Henry E.
Rose Shep K.
Szoke Ernest G.
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