Ether lipid-nucleoside covalent conjugates

Details Ether lipid-nucleoside covalent conjugates Ether lipid-nucleoside covalent conjugates

1995-04-07

1996-04-30

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 262, 536 2621, 536 2622, 536 2623, 536 267, 536 268, 536115, 536117, 536120, C07H 1920

Patent

active

055126715

ABSTRACT:
Ether lipid nucleoli covalent conjugates and derivatives thereof are disclosed, along with pharmaceutical compositions containing the same and methods of using the same to combat HIV-1 infections. Illustrative are 3'-Azido-3'-deoxythmidine-5'-monophosphate-D,L-3-octadecanamido-2-ethoxypr opane and 3'-Azido-3'-deoxythymidine-5'-butyrate-.gamma.-N,N,N-trimethyl -ammonium-.beta.-(1-phospho-2-ethoxy-3-hexadecyloxypropane).

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