Ether derivatives of pseudopterosin

Details Ether derivatives of pseudopterosin Ether derivatives of pseudopterosin

1995-06-07

1997-04-29

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 181, 514 25, A61K 3170, C07H 1500

Patent

active

056249110

ABSTRACT:
Methods for treating mammals to reduce pain and/or reduce inflammation are described based on administering to the mammals synthetic ether derivatives of pseudopterosin having the formula: ##STR1## wherein A is an alkyl, aryl or amide group having from 2 to 20 carbon atoms, R.sub.1, R.sub.2 and R.sub.3 are hydrogen or an acyl residue (--COR) having from 1 to 6 carbon atoms, R.sub.4 is hydrogen or --CH.sub.2 OH and R.sub.5 is a hydrocarbon having from 1 to 10 carbon atoms. Also disclosed are synthetic compositions having the above general formula which are useful in the described method.

REFERENCES:
patent: 4745104 (1988-05-01), Jacobs et al.
patent: 4849410 (1989-07-01), Jacobs et al.
Look et al., "The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae," Proc. Natl. Acad. Sci. USA, vol. 83, pp. 6238-6240, 1986.
Look et al., "The pseudopterosins: a new class of antiinflammatory and analgesic diterpene pentosides from the marine sea whip pseudopterogorgia elisabethae (Octocorallia)," J. Org. Chem. 1986, 51, 5140-5145.
Look et al., "The seco-pseudopterosins, new anti-inflammatory diterpene-glycosides from a caribbean gorgonian octocoral of the genus pseudopterogorgia," Tetrahedron, vol. 43, No. 15, pp. 3363-3370, 1987.
Roussis et al., "New antiinflammatory pseudopterosins from the marine octocoral pseudopterogorgia elisabethae," J. Org. Chem., 1990, vol. 55, No. 16, 4916-4922.

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