Ethanopyrrolo[1,2-b]isoquinolines

Details Ethanopyrrolo[1,2-b]isoquinolines Ethanopyrrolo[1,2-b]isoquinolines

1979-05-24

1980-07-22

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 63, 546124, 546125, 424258, 424256, C07D47108, C07D47118, C07D45102, A61K 31465

Patent

active

042140846

ABSTRACT:
Compounds of the tropane (8-azabicyclo[3.2.1]octane) series having an aromatic substituent in the 2-position and a carboalkoxy group in the 3-position are prepared by reacting a tropane-3-carboxylate having a double bond in the 2,3-position with an aryl Grignard reagent. Transformations of the substituent on nitrogen are subsequently effected. Compounds where the 3-carboalkoxy group is in the exo configuration possess hypoglycemic activity, and those where the 3-carboalkoxy group is in the endo configuration possess narcotic antagonist activity.

REFERENCES:
patent: 3813404 (1974-05-01), Clarke et al.
patent: 3901892 (1975-08-01), Clarke et al.
patent: 3951984 (1976-04-01), Kimura et al.
Kan-Fan et al., Acta Chemica Scandinavica, 27, pp. 1039-1052 (1973).

Affiliated with

Also associated with

Rating

Ethanopyrrolo[1,2-b]isoquinolines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ethanopyrrolo[1,2-b]isoquinolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ethanopyrrolo[1,2-b]isoquinolines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2179138